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Claims for Patent: 4,755,534

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Claims for Patent: 4,755,534

Title: Propenylamines, pharmaceutical compositions containing them and their use as pharmaceuticals
Abstract:A compound of the formula: ##STR1## wherein the double bond is in the trans configuration and R.sub.1 is a radical of formula IIa, ##STR2## R.sub.2, R.sub.3, R.sub.5, R.sub.7 and R.sub.8 are each hydrogen, R.sub.4 is methyl, and R.sub.6 is a radical of formula IIIa where R.sub.11 is n-butyl, tertiary butyl or phenyl or a chemotherapeutically acceptable acid addition salt thereof; processes for their production, their use as pharmaceuticals and pharmaceutical compositions containing them.
Inventor(s): Stuetz; Anton (Maria Enzersdorf, AT)
Assignee: Sandoz Ltd. (Basel, CH)
Application Number:06/646,724
Patent Claims: 1. A compound of the formula: ##STR78## wherein the double bond is in the trans configuration and R.sub.1 is a radical of formula IIa, ##STR79## R.sub.2, R.sub.3, R.sub.5, R.sub.7 and R.sub.8 are each hydrogen, R.sub.4 is methyl, and

R.sub.6 is a radical of formula IIIa

where R.sub.11 is n-butyl, tertiary butyl or phenyl or a chemotherapeutically acceptable acid addition salt thereof.

2. The trans compound according to claim 1 in which R.sub.1 is 1-naphthyl, R.sub.2 and R.sub.3 are H; R.sub.4 is CH.sub.3, R.sub.5 is H, and R.sub.6 is --C.tbd.C--C.sub.6 H.sub.5.

3. N-Methyl-N-(1-naphthylmethyl)-non-2(trans)en-4-ynyl-1-amine or a chemotherapeutically acceptable acid addition salt thereof.

4. N-Methyl-N-(1-naphthylmethyl)-6,6-dimethylhept-2(trans)-e n-4-ynyl-1-amine or a chemotherapeutically acceptable acid addition salt thereof.

5. A compound as claimed in claim 1 in the form of its hydrochloride.

6. A chemotherapeutical composition comprising an effective amount of a compound as claimed in claim 1 or a chemotherapeutically acceptable acid addition salt thereof in admixture with a chemotherapeutically acceptable diluent or carrier.

7. A method of treating diseases or infections caused by mycetes which comprises administering to a subject in need of treatment an effective amount of a compound as claimed in claim 1 or a chemotherapeutically acceptable acid addition salt thereof.
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