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Serving hundreds of leading biopharmaceutical companies globally:

QuintilesIMS
Federal Trade Commission
Covington
Farmers Insurance
Argus Health
Chinese Patent Office
Cerilliant
Julphar
Healthtrust

Generated: May 21, 2018

DrugPatentWatch Database Preview

Claims for Patent: 4,753,935

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Summary for Patent: 4,753,935
Title: Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions
Abstract:The compounds and pharmaceutical compositions of Formula A, wherein Z is hydrogen or --C(O)R, where R is lower alkyl or aryl, and the pharmaceutically acceptable salts thereof, are useful as immunosuppressive agents, anti-inflammatory agents, anti-tumor agents, anti-viral agents, and anti-psoriatic agents. ##STR1##
Inventor(s): Nelson; Peter H. (Los Altos, CA), Gu; Chee-Liang L. (Sunnyvale, CA), Allison; Anthony C. (Belmont, CA), Eugui; Elsie M. (Belmont, CA), Lee; William A. (Menlo Park, CA)
Assignee: Syntex (U.S.A.) Inc. (Palo Alto, CA)
Application Number:07/008,717
Patent Claims: 1. A compound represented by the formula: ##STR7## wherein: Z is hydrogen or --C(O)R,

where R is lower alkyl or aryl; or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 wherein Z is hydrogen.

3. The hydrochloride salt of the compound of claim 2.

4. The sulfate or bisulfate salt of the compound of claim 2.

5. The bisulfate salt of the compound of claim 2.

6. The compound of claim 1 where R is lower alkyl.

7. The compound of claim 6 wherein Z is --C(O)CH.sub.3.

8. The hydrochloride salt of the compound of claim 7.

9. The compound of claim 6 wherein Z is --C(O)CH.sub.2 CH.sub.3.

10. The compound of claim 6 wherein Z is pivaloyloxy.

11. The compound of claim 1 wherein Z is benzoyloxy.

12. A pharmaceutical composition comprising a pharmaceutically acceptable non-toxic excipient and a therapeutically effective amount of a compound of claim 1.

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Accenture
Fish and Richardson
Medtronic
AstraZeneca
Queensland Health
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Boehringer Ingelheim
Chinese Patent Office
Johnson and Johnson

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