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Claims for Patent: 4,753,802

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Claims for Patent: 4,753,802

Title: Verapamil dosage form
Abstract:An osmotic dosage form comprising verapamil and mannitol in a nonequilibrium ratio.
Inventor(s): Stephens; Sally I. (Mt. View, CA), Hamel; L. G. (Sunnyvale, CA)
Assignee: Alza Corporation (Palo Alto, CA)
Application Number:06/841,144
Patent Claims: 1. A dosage form for delivering the beneficial drug verapamil to a biological environment of use, the dosage for comprising:

(a) a wall comprising in at least a part a composition comprising a cellulose acylate, which wall is permeable to the passage of fluid, impermeable to the passage of verapamil, and surrounds and forms:

(b) a compartment;

(c) a dosage amount of verapamil in the compartment, with the proviso that said verapamil is present with mannitol in the compartment in a nonequilibrium ratio of 0.9 to 1.1; and,

(d) at least one passageway in the wall connecting the compartment with the exterior of the dosage form for dispensing verapamil to the environment of use over time.

2. The dosage form for delivering the beneficial drug verapamil according to claim 1, wherein verapamil is present as a therapeutically acceptable addition salt.

3. The dosage forms for delivering the beneficial drug verapamil according to claim 1, wherein verapamil is present in the dosage form as verapamil hydrochloride.

4. The dosage form for delivering the beneficial drug verapamil according to claim 1, wherein the cellulose acylate is cellulose acetate having an acetyl content of 39.8%.

5. The dosage form for delivering the beneficial drug verapamil according to claim 1, wherein the cellulose acylate is cellulose acetate having an acetyl content of 32%.

6. The dosage form for delivering the beneficial drug verapamil according to claim 1, wherein wall composition comprises a cellulose acylate having an acetyl content of 39.8% and a cellulose acylate having an acetyl content of 32%.

7. The dosage form for delivering the beneficial drug verapamil according to claim 1, wherein the nonequilibrium ratio is 1.

8. The dosage form for delivering the beneficial drug verapamil according to claim 1, wherein the dosage form comprises from 50 to 600 mg of verapmil.

9. The dosage form for delivering the beneficial drug verapamil according to claim 1, wherein the dosage form comprises from 115 to 125 mg of verapamil pharmaceutically acceptable salt.

10. The dosage form for delivering the beneficial drug verapamil according to claim 1, wherein the dosage form comprises 235 to 245 mg of verapamil pharmaceutically acceptable salt.

11. The dosage form for delivering the beneficial drug verapamil according to claim 1, wherein the environment of use in the gastrointestinal tract, and the dosage form is adapted for oral admittance into said environment of use.
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