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Generated: September 23, 2017

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Title: Base addition salts of omeprazole
Abstract:Novel salts of omeprazole with Li.sup.+, Na.sup.+, K.sup.+, Mg.sup.2+, Ca.sup.2+, Ti.sup.4+, N.sup.+ (R.sup.1).sub.4 or ##STR1## as cation; processes for their preparation thereof, pharmaceutical compositions containing such salts and their use in medicine.
Inventor(s): Brandstrom; Arne E. (Gothenburg, SE)
Assignee: Aktiebolaget Hassle (SE)
Application Number:06/854,739
Patent Claims: 1. A compound of the formula ##STR9## wherein n is 1, 2, or 4; and A.sup.n+ is Li.sup.+, Na.sup.+, K.sup.+, Mg.sup.2+, or Ca.sup.2+.

2. A compound according to claim 1 wherein A.sup.n+ is Na.sup.+, K.sup.+, Mg.sup.2+ or Ca.sup.2+.

3. A compound according to claim 1 wherein A.sup.n+ is Na.sup.+.

4. A compound according to claim 1 wherein A.sup.n+ is Mg.sup.2+.

5. A pharmaceutical composition for inhibiting gastric acid secretion comprising a compound according to claim 1 in an amount effective to inhibit gastric acid secretion and a pharmaceutically acceptable carrier.

6. A pharmaceutical composition for inhibiting gastric acid secretion comprising a compound according to claim 2 in an amount effective to inhibit gastric acid secretion and a pharmaceutically acceptable carrier.

7. A pharmaceutical composition for inhibiting gastric acid secretion comprising a compound according to claim 3 in an amount effective to inhibit gastric acid secretion and a pharmaceutically acceptable carrier.

8. A pharmaceutical composition for inhibiting gastric acid secretion comprising a compound according to claim 4 in an amount effective to inhibit gastric acid secretion and a pharmaceutically acceptable carrier.

9. A method for inhibiting gastric acid secretion by administering to mammals an amount of a compound as defined in claim 1 sufficient to inhibit gastric acid secretion.

10. A method for inhibiting gastric acid secretion by administering to mammals an amount of a compound as defined in claim 2 sufficient to inhibit gastric acid secretion.

11. A method for inhibiting gastric acid secretion by administering to mammals an amount of a compound as defined in claim 3 sufficient to inhibit gastric acid secretion.

12. A method for inhibiting gastric acid secretion by administering to mammals an amount of a compound as defined in claim 4 sufficient to inhibit gastric acid secretion.

13. A method for the treatment of gastrointestinal inflammatory diseases in mammals by administering to mammals an amount of a compound as defined in claim 1 sufficient to treat gastrointestinal inflammatory disease.

14. A method for the treatment of gastrointestinal inflammatory diseases in mammals by administering to mammals an amount of a compound as defined in claim 2 sufficient to treat gastrointestinal inflammatory disease.

15. A method for the treatment of gastrointestinal inflammatory diseases in mammals by administering to mammals an amount of a compound as defined in claim 3 sufficient to treat gastrointestinal inflammatory disease.

16. A method for the treatment of gastrointestinal inflammatory diseases in mammals by administering to mammals an amount of a compound as defined in claim 4 sufficient to treat gastrointestinal inflammatory disease.

17. A method for providing gastrointestinal cytoprotective effects in mammals by administering to mammals an amount of a compound as defined in claim 1 sufficient to provide gastrointestinal cytoprotective effects.

18. A method for providing gastrointestinal cytoprotective effects in mammals by administering to mammals an amount of a compound as defined in claim 2 sufficient to provide gastrointestinal cytoprotective effects.

19. A method for providing gastrointestinal cytoprotective effects in mammals by administering to mammals an amount of a compound as defined in claim 3 sufficient to provide gastrointestinal cytoprotective effects.

20. A method for providing gastrointestinal cytoprotective effects in mammals by administering to mammals an amount of a compound as defined in claim 4 sufficient to provide gastrointestinal cytoprotective effects.
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Serving 500+ biopharmaceutical companies globally:

Johnson and Johnson
McKinsey
Express Scripts
Argus Health
Farmers Insurance
Daiichi Sankyo
Medtronic
Chubb
Novartis
Harvard Business School

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