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Claims for Patent: 4,724,233

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Claims for Patent: 4,724,233

Title: Therapeutical application of phosphonylmethoxyalkyl adenines
Abstract:The (S) and (RS) forms of certain phosphonylmethoxyalkyl adenines and their salts have an antiviral effect against several DNA viruses and can be used for the treatment of virus diseases in human and veterinary medicine.
Inventor(s): De Clercq; Erik (Louvain, BE), Holy; Antonin (Trebesovska, CS), Rosenberg; Ivan (Obrancu min, CS)
Assignee: Stichting Rega VZW (Louvain, BE) Ceskoslovenska Akademie VED (Prague, CS)
Application Number:06/854,087
Patent Claims: 1. A method for treating virus diseases, which comprises administering to a patient in need of said treatment an effective antiviral amount of a phosphonylmethoxyalkyladenine of the formula (I) ##STR3## wherein R.sup.1 is methylene, --CH(OH)--CH.sub.2 -- or ##STR4## and R.sup.2 is a hydroxyl group, and, wherein, when R.sup.1 is different from methylene, R.sup.1 and R.sup.2 may be linked with each other to form a cyclic ester group, said adenine derivative being in (RS) or (S) form when R.sup.1 is different from methylene and further being in the form of a free acid or a salt thereof wherein the salts are selected from the group consisting of alkali metal, ammonia, and amine salts.

2. The method of claim 1, wherein said compound is (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine.

3. The method of claim 1, wherein said virus disease is caused by a herpes virus.

4. A method of claim 1, wherein said virus disease is caused by pox virus.

5. The method of claim 1, wherein said virus disease is caused by a retrovirus.

6. The method of claim 1, wherein said virus disease is caused by reovirus.

7. The method of claim 1, wherein said virus disease is caused by parainfluenza virus.

8. The method of claim 1, wherein said virus disease is caused by sindbis virus.

9. The method of claim 1, wherein said virus disease is caused by polio virus.

10. The method of claim 1, wherein said virus disease is caused by vesicular stomatitis virus.

11. The method of claim 1, wherein said virus disease is caused by vaccinia.

12. The method of claim 1, wherein said virus disease is caused by moloney sarcoma virus.
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