Claims for Patent: 4,724,232

Summary for Patent: 4,724,232

Title:	Treatment of human viral infections
Abstract:	Treatment of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof. Also disclosed is the use of the 5'-mono-, di- and triphosphate of 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof for the same purpose.
Inventor(s):	Rideout; Janet L. (Raleigh, NC), Barry; David W. (Chapel Hill, NC), Lehrman; Sandra N. (Durham, NC), St. Clair; Martha H. (Durham, NC), Furman; Phillip A. (Durham, NC)
Assignee:	Burroughs Wellcome Co. (Research Triangle Park, NC)
Application Number:	06/776,899
Patent Claims:	1. A method of treating a human having acquired immunodeficiency syndrome comprising the oral administration of an effective acquired immunodeficiency syndrome treatment amount of 3'-azido-3'-deoxythymidine to said human. 2. The method of claim 1 in which a capsule containing 3'-azido-3'-deoxythymidine is orally administered. 3. The method of claim 1 in which a tablet containing 3'-azido-3'-deoxythymidine is orally administered. 4. The method of claim 1 in which an aqueous solution containing 3'-azido-3'-deoxythymidine is orally administered. 5. The method of claim 1 in which an aqueous suspension containing 3'-azido-3'-deoxythymidine is orally administered. 6. The method of claim 1 in which a non-aqueous suspension containing 3'-azido-3'-deoxythymidine is orally administered. 7. A method of treating a human having acquired immunodeficiency syndrome comprising the parenteral administration of an effective acquired immunodeficiency syndrome treatment amount of 3'-azido-3'-deoxythymidine in a sterile injectable formulation to said human. 8. A method of treating a human having acquired immunodeficiency syndrome comprising the administration of an effective acquired immunodeficiency syndrome treatment amount of 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable alkali metal, alkaline earth or ammonium salt thereof to said human. 9. The method of claim 8 in which 3'-azido-3'-deoxythymidine or the salt thereof is administered orally or parenterally. 10. The method of claim 9 in which the salt is administered. 11. The method of claim 9 in which a tablet, capsule or sterile injectable formulation containing 3'-azido-3'-deoxythymidine or said salt thereof is administerable. 12. The method of claim 8 in which an aqueous or non-aqueous solution or suspension containing 3'-azido-3'-deoxythymidine is orally administered. 13. A method of treating a human having acquired immunodeficiency syndrome related complex comprising the oral administration of an effective acquired immunodeficiency syndrome related complex treatment amount of 3'-azido-3'-deoxythymidine to said human. 14. The method of claim 13 in which a capsule containing 3'-azido-3'-deoxythymidine is orally administered. 15. The method of claim 13 in which a tablet containing 3'-azido-3'-deoxythymidine is orally administered. 16. The method of claim 13 in which an aqueous solution containing 3'-azido-3'-deoxythymidine is orally administered. 17. The method of claim 13 in which an aqueous suspension containing 3'-azido-3'-deoxythymidine is orally administered. 18. The method of claim 13 in which a non-aqueous suspension containing 3'-azido-3'-deoxythymidine is orally administered. 19. A method of treating a human having acquired immunodeficiency syndrome related complex comprising the parenteral administration of an effective acquired immunodeficiency syndrome related complex treatment amount of 3'-azido-3'-deoxythymidine in a sterile injectable formulation to said human. 20. A method of treating a human having acquired immunodeficiency syndrome related complex comprising the administration of an effective acquired immunodeficiency syndrome related complex treatment amount of 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable alkali metal, alkaline earth or ammonium salt thereof to said human. 21. The method of claim 20 in which 3'-azido-3'-deoxythymidine or the salt thereof is administered orally or parenterally. 22. The method of claim 21 in which the salt is administered. 23. The method of claim 20 in which a tablet, capsule or sterile injectable formulation containing 3'-azido-3'-deoxythymidine or said salt thereof is administered. 24. The method of claim 20 in which an aqueous or non-aqueous solution or suspension containing 3'-azido-3'-deoxythymidine is orally administered.