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Claims for Patent: 4,724,232

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Claims for Patent: 4,724,232

Title: Treatment of human viral infections
Abstract:Treatment of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof. Also disclosed is the use of the 5'-mono-, di- and triphosphate of 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof for the same purpose.
Inventor(s): Rideout; Janet L. (Raleigh, NC), Barry; David W. (Chapel Hill, NC), Lehrman; Sandra N. (Durham, NC), St. Clair; Martha H. (Durham, NC), Furman; Phillip A. (Durham, NC)
Assignee: Burroughs Wellcome Co. (Research Triangle Park, NC)
Application Number:06/776,899
Patent Claims: 1. A method of treating a human having acquired immunodeficiency syndrome comprising the oral administration of an effective acquired immunodeficiency syndrome treatment amount of 3'-azido-3'-deoxythymidine to said human.

2. The method of claim 1 in which a capsule containing 3'-azido-3'-deoxythymidine is orally administered.

3. The method of claim 1 in which a tablet containing 3'-azido-3'-deoxythymidine is orally administered.

4. The method of claim 1 in which an aqueous solution containing 3'-azido-3'-deoxythymidine is orally administered.

5. The method of claim 1 in which an aqueous suspension containing 3'-azido-3'-deoxythymidine is orally administered.

6. The method of claim 1 in which a non-aqueous suspension containing 3'-azido-3'-deoxythymidine is orally administered.

7. A method of treating a human having acquired immunodeficiency syndrome comprising the parenteral administration of an effective acquired immunodeficiency syndrome treatment amount of 3'-azido-3'-deoxythymidine in a sterile injectable formulation to said human.

8. A method of treating a human having acquired immunodeficiency syndrome comprising the administration of an effective acquired immunodeficiency syndrome treatment amount of 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable alkali metal, alkaline earth or ammonium salt thereof to said human.

9. The method of claim 8 in which 3'-azido-3'-deoxythymidine or the salt thereof is administered orally or parenterally.

10. The method of claim 9 in which the salt is administered.

11. The method of claim 9 in which a tablet, capsule or sterile injectable formulation containing 3'-azido-3'-deoxythymidine or said salt thereof is administerable.

12. The method of claim 8 in which an aqueous or non-aqueous solution or suspension containing 3'-azido-3'-deoxythymidine is orally administered.

13. A method of treating a human having acquired immunodeficiency syndrome related complex comprising the oral administration of an effective acquired immunodeficiency syndrome related complex treatment amount of 3'-azido-3'-deoxythymidine to said human.

14. The method of claim 13 in which a capsule containing 3'-azido-3'-deoxythymidine is orally administered.

15. The method of claim 13 in which a tablet containing 3'-azido-3'-deoxythymidine is orally administered.

16. The method of claim 13 in which an aqueous solution containing 3'-azido-3'-deoxythymidine is orally administered.

17. The method of claim 13 in which an aqueous suspension containing 3'-azido-3'-deoxythymidine is orally administered.

18. The method of claim 13 in which a non-aqueous suspension containing 3'-azido-3'-deoxythymidine is orally administered.

19. A method of treating a human having acquired immunodeficiency syndrome related complex comprising the parenteral administration of an effective acquired immunodeficiency syndrome related complex treatment amount of 3'-azido-3'-deoxythymidine in a sterile injectable formulation to said human.

20. A method of treating a human having acquired immunodeficiency syndrome related complex comprising the administration of an effective acquired immunodeficiency syndrome related complex treatment amount of 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable alkali metal, alkaline earth or ammonium salt thereof to said human.

21. The method of claim 20 in which 3'-azido-3'-deoxythymidine or the salt thereof is administered orally or parenterally.

22. The method of claim 21 in which the salt is administered.

23. The method of claim 20 in which a tablet, capsule or sterile injectable formulation containing 3'-azido-3'-deoxythymidine or said salt thereof is administered.

24. The method of claim 20 in which an aqueous or non-aqueous solution or suspension containing 3'-azido-3'-deoxythymidine is orally administered.
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