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Last Updated: March 28, 2024

Claims for Patent: 4,711,880


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Summary for Patent: 4,711,880
Title: Crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
Abstract:The invention relates to a novel crystal modification, containing water of crystallization, of disodium 3-amino-1-hydroxypropane-1,1-diphosphonate of the formula ##STR1## and to a process for the manufacture thereof. This modification is suitable for the oral treatment of disorders of the calcium and phosphate metabolism and associated diseases in warm-blooded animals.
Inventor(s): Stahl; Peter H. (Freiburg, DE), Schmitz; Beat (Allschwil, CH)
Assignee: Ciba-Geigy Corporation (Ardsley, NY) Henkel Kommanditgesellschaft auf Aktien (Dusseldorf-Holthausen, DE)
Application Number:06/905,097
Patent Claims: 1. Disodium 3-amino-1-hydroxypropane-1,1-diphosphonate of the formula ##STR3## in a crystalline form that contains water of crystallisation.

2. Disodium 3-amino-1-hydroxypropane-1,1-diphosphonate in a crystalline form that contains water of crystallisation according to claim 1, characterised by a water content of from approximately 24.1 to approximately 24.5% by weight.

3. Disodium 3-amino-1-hydroxypropane-1,1-diphosphonate according to claim 1 in crystalline pentahydrate form.

4. Disodium 3-amino-1-hydroxypropane-1,1-diphosphonate according to claim 1, obtainable by crystallisation of disodium 3-amino-1-hydroxypropane-1,1-diphosphonate from a water-containing solution and drying at normal or slightly elevated temperature.

5. Disodium 3-amino-1-hydroxypropane-1,1-diphosphonate according to claim 1, obtainable by crystallisation from an at least saturated aqueous solution, crystal formation taking place at at least approximately 50.degree. C., and drying at from approximately 15.degree. C. to approximately 60.degree. C.

6. Disodium 3-amino-1-hydroxypropane-1,1-diphosphonate according to claim 1, obtainable by crystallisation from an at least saturated aqueous solution, crystal formation taking place at from approximately 50.degree. C. to approximately 80.degree. C., and drying at from approximately 18.degree. C. to approximately 25.degree. C. or at from approximately 35.degree. C. to approximately 40.degree. C.

7. Disodium 3-amino-1-hydroxypropane-1,1-diphosphonate according to claim 1, obtainable by the action of moist air having a relative atmospheric humidity of from approximately 95% to approximately 99% at from approximately 20.degree. C. to approximately 25.degree. C.

8. Disodium 3-amino-1-hydroxypropane-1,1-diphosphonate in a crystalline form that contains water of crystallisation according to claim 1, characterised by the following lattice spacings (d-values) and relative line intensities (intensities) of its X-ray powder pattern (camera according to Guinier-de-Wolff, radiation source: copper-K.sub..alpha.):

9. Pharmaceutical preparations intended for enteral administration to warm-blooded animals, containing disodium 3-amino-1-hydroxypropane-1,1-diphosphonate in addition to customary pharmaceutical auxiliaries, characterised in that they contain the mentioned active ingredient in a crystalline form that contains water of crystallisation according to claim 1.

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