Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving leading biopharmaceutical companies globally:

Daiichi Sankyo
Harvard Business School
Argus Health
AstraZeneca
Express Scripts
UBS
Julphar
Queensland Health
Baxter
Citi

Generated: February 22, 2018

DrugPatentWatch Database Preview

Claims for Patent: 4,703,063

« Back to Dashboard

Summary for Patent: 4,703,063
Title: Sulfamoyl substituted phenethylamine derivatives and process of producing them
Abstract:Novel sulfamoyl-substituted phenethylamine derivatives which exhibit .alpha.-adrenergic blocking action and are useful as an antihypertensive agent and an agent for the treatment of congestive heart failure.
Inventor(s): Imai; Kazuo (Saitama, JP), Niigata; Kunihiro (Saitama, JP), Fujikura; Takashi (Saitama, JP), Hashimoto; Shinichi (Chiba, JP), Takenaka; Toichi (Tokyo, JP)
Assignee: Yamanouchi Pharmaceutical Co., Ltd. (Tokyo, JP)
Application Number:06/756,790
Patent Claims: 1. Sulfamoyl-substituted phenethylamine derivatives represented by the general formula ##STR79## wherein R.sub.1 represents an amino group or a mono- or di-lower alkylamino group; R.sub.2 represents a hydroxyl group, a lower alkyl group, or a lower alkoxy group; R.sub.3 represents a hydrogen atom, a lower alkoxy group or a lower alkyl group; R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, and R.sub.9 each represents a hydrogen atom or a lower alkyl group; R.sub.10 represents a hydrogen atom, a lower alkyl group, or a lower alkoxy group; and Y represents an oxygen atom, and the salts thereof.

2. A pharmaceutical composition containing an effective .alpha.-adrenergic antagonistic amount of a compound of claim 1 and a pharmaceutically acceptable excipient.

3. The salts of the sulfamoyl-substituted phenethylamine derivatives as claimed in claim 1 wherein R.sub.3 is a lower alkyl group or a lower alkoxy group.

4. The compound of claim 1 wherein R.sub.3 is a hydrogen atom and the salts thereof.

5. The compound of claim 1 wherein R.sub.3 is a lower alkyl group and the salts thereof.

6. The compound of claim 1 which is a racemic compound.

7. The compound of claim 1 which is a mixture of racemic compounds.

8. The compound of claim 1 which is an optically active isomer.

9. The isomer of claim 8 which is the (+) isomer.

10. The isomer of claim 8 which is the (-) isomer.

11. The optically active isomers of the compound of claim 7.

12. The isomer of claim 11 which is the (+) isomer.

13. The isomer of claim 11 which is the (-) isomer.

14. The compound of claim 1 which is 5-{2-[2-(2-ethoxyphenoxy)ethylamino]-2-methylethyl}-2-methoxybenzenesulfon amide.

15. The compound of claim 1 which is 2-methoxy-5-{2-[2-(2-methoxyphenoxy)ethylamino]-2-methylethyl}benzenesulfo namide.

16. The compound of claim 1 which is 5-{2-[2-(2-methoxyphenoxy)ethylamino]-2-methylethyl}-2-methylbenzenesulfon amide.

17. The compound of claim 1 which is 5-{2-[2-(2-methoxyphenoxy)ethylamino]ethyl}-2-methylbenzenesulfonamide.

18. The compound of claim 1 which is 2-methoxy-5-{2-[2-(2-methoxyphenoxy)ethylamino]-2-methylethyl}-N-methylben zenesulfonamide.

19. The compound of claim 1 which is 2-methoxy-5-{2-[2-(2-methoxyphenoxy)ethylamino]-2-methylethyl}-N,N-dimethy lbenzenesulfonamide.

For more information try a trial or see the plans and pricing

Serving hundreds of leading biopharmaceutical companies globally:

Johnson and Johnson
Mallinckrodt
Express Scripts
Chubb
Citi
Moodys
Medtronic
Accenture
Chinese Patent Office

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

botpot