Claims for Patent: 4,694,007
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Summary for Patent: 4,694,007
| Title: | Use of trimetrexate as antiparasitic agent |
| Abstract: | A method of treating infections of Toxoplasmosis or P. carini comprising administering to the host an effective amount of trimetrexate, (2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline. |
| Inventor(s): | Carmen Allegra, James C. Drake, Bruce A. Chabner, Henry Masur, Joseph A. Kovacs |
| Assignee: | HEALTH AND HUMAN SERVICES United States, Secretary of, Department of , US Department of Health and Human Services |
| Application Number: | US06/865,055 |
| Patent Claims: |
1. A method for treating infections of Toxoplasmosis or P. carinii comprising administering to a mammelian host in need of said treatment an amount of trimetrexate effective to treat said Toxoplasmosis or P. carinii. 2. The method of claim 1 wherein the trimetrexate is administered orally. 3. The method of claim 1 wherein the trimetrexate is administered in a dosage of about 30 mg/kg. 4. The method of claim 1 wherein the trimetrexate is administered in combination with leucovorin. 5. A method of inhibiting dihydrofolate reductase production by T. gondii or P. carinii in a mammalian host comprising administering to said mammalian host an amount of trimetrexate effective to inhibit said dihydrofolate reductase production. |
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ISSN: 2162-2639
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