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Claims for Patent: 4,694,007

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Claims for Patent: 4,694,007

Title: Use of trimetrexate as antiparasitic agent
Abstract:A method of treating infections of Toxoplasmosis or P. carini comprising administering to the host an effective amount of trimetrexate, (2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline.
Inventor(s): Allegra; Carmen (Vienna, VA), Drake; James C. (Ijamsville, MD), Chabner; Bruce A. (Potomac, MD), Masur; Henry (Bethesda, MD), Kovacs; Joseph A. (Bethesda, MD)
Assignee: The United States of America as represented by the Secretary of the (Washington, DC)
Application Number:06/865,055
Patent Claims: 1. A method for treating infections of Toxoplasmosis or P. carinii comprising administering to a mammelian host in need of said treatment an amount of trimetrexate effective to treat said Toxoplasmosis or P. carinii.

2. The method of claim 1 wherein the trimetrexate is administered orally.

3. The method of claim 1 wherein the trimetrexate is administered in a dosage of about 30 mg/kg.

4. The method of claim 1 wherein the trimetrexate is administered in combination with leucovorin.

5. A method of inhibiting dihydrofolate reductase production by T. gondii or P. carinii in a mammalian host comprising administering to said mammalian host an amount of trimetrexate effective to inhibit said dihydrofolate reductase production.
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