Last Updated: June 24, 2026

Claims for Patent: 4,689,333

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Summary for Patent: 4,689,333

Title:	2-(2-pyridylmethylthio (sulfinyl)) benzimidazoles
Abstract:	The compound of the formula ##STR1## wherein R1 is hydrogen, methoxy or trifluoromethyl, R2 and R3 are independently hydrogen or methyl, R4 is a C2-5 fluorinated alkyl and n denotes 0 or 1, or a pharmacologically acceptable salt thereof is novel, and useful for prophylaxis and therapy of digestive ulcers (e.g. gastric ulcer, duodenal ulcer) and gastritis.
Inventor(s):	Akira Nohara, Yoshitaka Maki
Assignee:	Takeda Pharmaceutical Co Ltd
Application Number:	US06/937,193
Patent Claims:	1. A phramaceutical composition for preventing or treating digestive ulcers or gastritis, which contains an effective amount of a compound of the formula ##STR8## wherein R1 is hydrogen, methoxy or trifluoromethyl, R2 and R3 are independently hydrogen or methyl, R4 is a C2-5 fluorinated alkyl and n denotes 0 or 1, or a pharmacologically acceptable salt thereof, and pharmacologically acceptable carriers. 2. A phamaceutical composition according to claim 1, wherein R1 is hydrogen or trifluoromethyl. 3. A pharmaceutical composition according to claim 1, wherein R3 is hydrogen. 4. A pharmaceutical composition according to claim 1, wherein n is 1. 5. A phamaceutical composition according to claim 1, wherein R1 and R3 are hydrogen, R2 is methyl, R4 is 2,2,2-trifluoroethyl and n is 1. 6. A method for preventing or treating digestive ulcers or gastritis, which comprises administering a compound of the formula ##STR9## wherein R1 is hydrogen, methoxy or trifluoromethyl, R2 and R3 are independently hydrogen or methyl, R4 is a C2-5 fluorinated alkyl and n denotes 0 or 1, or a pharmacologically acceptable salt thereof, and pharmacologically acceptable carriers. 7. A method according to claim 6, wherein R1 is hydrogen or trifluoromethyl. 8. A method according to claim 6, wherein R3 is hydrogen. 9. A method according to claim 6, wherein n is 1. 10. A method according to claim 6, wherein R1 and R3 are hydrogen, R2 is methyl, R4 is 2,2,2-trifluoroethyl and n is 1.

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