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Serving hundreds of leading biopharmaceutical companies globally:

Dow
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Queensland Health
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Baxter
Healthtrust
Harvard Business School
Federal Trade Commission
Daiichi Sankyo

Generated: May 28, 2018

DrugPatentWatch Database Preview

Claims for Patent: 4,689,333

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Summary for Patent: 4,689,333
Title: 2-(2-pyridylmethylthio (sulfinyl)) benzimidazoles
Abstract:The compound of the formula ##STR1## wherein R.sup.1 is hydrogen, methoxy or trifluoromethyl, R.sup.2 and R.sup.3 are independently hydrogen or methyl, R.sup.4 is a C.sub.2-5 fluorinated alkyl and n denotes 0 or 1, or a pharmacologically acceptable salt thereof is novel, and useful for prophylaxis and therapy of digestive ulcers (e.g. gastric ulcer, duodenal ulcer) and gastritis.
Inventor(s): Nohara; Akira (Kyoto, JP), Maki; Yoshitaka (Kyoto, JP)
Assignee: Takeda Chemical Industries, Ltd. (Osaka, JP)
Application Number:06/937,193
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 4,689,333
Patent Claims: 1. A phramaceutical composition for preventing or treating digestive ulcers or gastritis, which contains an effective amount of a compound of the formula ##STR8## wherein R.sup.1 is hydrogen, methoxy or trifluoromethyl, R.sup.2 and R.sup.3 are independently hydrogen or methyl, R.sup.4 is a C.sub.2-5 fluorinated alkyl and n denotes 0 or 1, or a pharmacologically acceptable salt thereof, and pharmacologically acceptable carriers.

2. A phamaceutical composition according to claim 1, wherein R.sup.1 is hydrogen or trifluoromethyl.

3. A pharmaceutical composition according to claim 1, wherein R.sup.3 is hydrogen.

4. A pharmaceutical composition according to claim 1, wherein n is 1.

5. A phamaceutical composition according to claim 1, wherein R.sup.1 and R.sup.3 are hydrogen, R.sup.2 is methyl, R.sup.4 is 2,2,2-trifluoroethyl and n is 1.

6. A method for preventing or treating digestive ulcers or gastritis, which comprises administering a compound of the formula ##STR9## wherein R.sup.1 is hydrogen, methoxy or trifluoromethyl, R.sup.2 and R.sup.3 are independently hydrogen or methyl, R.sup.4 is a C.sub.2-5 fluorinated alkyl and n denotes 0 or 1, or a pharmacologically acceptable salt thereof, and pharmacologically acceptable carriers.

7. A method according to claim 6, wherein R.sup.1 is hydrogen or trifluoromethyl.

8. A method according to claim 6, wherein R.sup.3 is hydrogen.

9. A method according to claim 6, wherein n is 1.

10. A method according to claim 6, wherein R.sup.1 and R.sup.3 are hydrogen, R.sup.2 is methyl, R.sup.4 is 2,2,2-trifluoroethyl and n is 1.

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Serving hundreds of leading biopharmaceutical companies globally:

Federal Trade Commission
Merck
Colorcon
AstraZeneca
McKinsey
McKesson
Fuji
Express Scripts
Daiichi Sankyo

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