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Claims for Patent: 4,686,214

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Claims for Patent: 4,686,214

Title: Anti-inflammatory compounds for ophthalmic use
Abstract:Anti-inflammatory compounds and a method of treating inflamed ocular tissue utilizing these compounds are described. The steroidal actives are advantageously characterized in that they do not cause any significant increase in intraocular pressure during chronic use.
Inventor(s): Boltralik; John J. (Fort Worth, TX)
Assignee: Alcon Laboratories, Inc. (Fort Worth, TX)
Application Number:06/792,992
Patent Claims: 1. A method of treating ocular inflammation which comprises applying to the eye an anti-inflammatory effective amount of a compound of the following structure: ##STR3## wherein: X=a member of the group consisting of H and halogen;

Y=a member of the group consisting of H.sub.2 H(OH), H(OAcyl) and O;

R.sup.1 =a member of the group consisting of H, CH.sub.3 and halogen;

R.sup.2 =alkyl having 1-4 carbon atoms;

R.sup.3 =a member of the group consisting of H, OAcyl, Oalkyl, and CH.sub.3 ;

R.sup.4 =a member of the group consisting of H and alkyl having 1-4 carbon atoms; and C.sub.1 -C.sub.2 and C.sub.6 -C.sub.7 are selected from a saturated and an unsaturated bond.

2. A method according to claim 1 wherein the compound is: ##STR4##
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