|Abstract:||This invention provides a method of producing analgesia in mammals which comprises administering codeine and fluoxetine or norfluoxetine. Pharmaceutical formulations useful in this method are also provided.|
|Inventor(s):||Hynes; Martin D. (Carmel, IN)|
|Assignee:||Eli Lilly and Company (Indianapolis, IN)|
1. A method of potentiating codeine analgesia in mammals which comprises the administration to said mammal of an effective potentiating amount of fluoxetine or norfluoxetine in the time
range between 24 hours before and 2 hours after the administration of codeine.
2. The method of claim 1 wherein the compounds are administered simultaneously.
3. The method of claim 2 employing fluoxetine hydrochloride.
4. The method of claim 3 wherein about 10 to about 80 mg of fluoxetine hydrochloride and from about 10 to about 60 mg of codeine sulfate are administered.
5. A pharmaceutical formulation which comprises fluoxetine or norfluoxetine, codeine, and a pharmaceutically acceptable carrier, diluent, or excipient therefor wherein the ratio of fluoxetine or norfluoxetine to codeine is about 7:1 to about 1:1 and the combination of active ingredients is present in an effective amount.
6. A formulation according to claim 5 employing fluoxetine hydrochloride.
7. A formulation according to claim 6 wherein the ratio of fluoxetine hydrochloride to codeine sulfate is approximately 2:1.
8. A formulation according to claim 7 employing from about 10 to about 80 mg of fluoxetine hydrochloride and from about 10 to about 60 mg of codeine sulfate.
9. A formulation according to claim 8 which is formulated for oral administration.