|Title:|| Stable prostaglandin E gels utilizing colloidal silicon dioxide as a gel-forming agent|
|Abstract:||The present invention provides an improved class of stable gels of prostaglandin E compounds prepared from solutions of prostaglandin E compounds in a pharmaceutically acceptable, stabilizing organic solvent, e.g., triacetin, gelled by the addition of colloidal silicon dioxide.|
|Inventor(s):|| Johnson; Brian S. (Crawley, GB) |
|Assignee:|| The Upjohn Company (Kalamazoo, MI) |
1. In a stable dosage form of PGE.sub.2 consisting essentially of PGE.sub.2 in triacetin, an improvement which comprises: colloidal silicon dioxide (CSD) as a gel forming additive
thereto in a concentration by weight of CSD in said stable dosage form from about not less than 8 percent to about not more than 15 percent.