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Claims for Patent: 4,680,312

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Claims for Patent: 4,680,312

Title: Stable prostaglandin E gels utilizing colloidal silicon dioxide as a gel-forming agent
Abstract:The present invention provides an improved class of stable gels of prostaglandin E compounds prepared from solutions of prostaglandin E compounds in a pharmaceutically acceptable, stabilizing organic solvent, e.g., triacetin, gelled by the addition of colloidal silicon dioxide.
Inventor(s): Johnson; Brian S. (Crawley, GB)
Assignee: The Upjohn Company (Kalamazoo, MI)
Application Number:06/674,357
Patent Claims: 1. In a stable dosage form of PGE.sub.2 consisting essentially of PGE.sub.2 in triacetin, an improvement which comprises: colloidal silicon dioxide (CSD) as a gel forming additive thereto in a concentration by weight of CSD in said stable dosage form from about not less than 8 percent to about not more than 15 percent.
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