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Claims for Patent: 4,677,191

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Claims for Patent: 4,677,191

Title: Copolymer and method for producing the same
Abstract:A copolymer of lactic acid and glycolic acid which has a weight-average molecular weight of not less than about 5000 and a dispersity of about 1.5 to 2 is advantageously used as a biodegradable polymer for medical preparation.
Inventor(s): Tanaka; Motoaki (Urawa, JP), Ogawa; Yasuaki (Ibaraki, JP), Miyagawa; Tsutomu (Kawagoe, JP), Watanabe; Toshio (Kawagoe, JP)
Assignee: Wada Pure Chemical Ind., Ltd. (Higashi, JP) Takeda Chemical Industries, Ltd. (Higashi, JP)
Application Number:06/751,672
Patent Claims: 1. A copolymer of lactic acid and glycolic acid free from catalyst, which has a weight-average molecular weight of about 5,000 to 30,000 and a dispersity of about 1.5 to 2.

2. A copopymer as claimed in claim 1, wherein the copolymer ratio is about 50 to 95 weight % of lactic acid and about 50 to 5 weight % of glycolic acid.

3. A copolymer as claimed in claim 1, wherein the copolymer ratio is about 60 to 95 weight % of lactic acid and about 40 to 5 weight % of glycolic acid.

4. A copolymer as claimed in claim 1, wherein the copolymer ratio is about 60 to 85 weight % of lactic acid and about 40 to 15 weight % of glycolic acid.

5. A copolymer as claimed in claim 1, wherein the copolymer ratio is about 75.+-.2 mol % of lactic acid and about 25.+-.2 mol % of glycolic acid.

6. A method for producing a copolymer of lactic acid and glycolic acid, the copolymer having a weight-average molecular weight of not less than about 5,000 and a dispersity of about 1.5 to 2, which comprises subjecting lactic acid and glycolic acid or a low molecular polymer or copolymer of them to a polycondensation reaction under heating and reduced pressure in the absence of a catalyst.

7. A method as claimed in claim 6, wherein the low molecular copolymer of lactic acid and glycolic acid is produced by subjecting lactic acid and glycolic acid to undergo a condensation reaction in the absence of a catalyst and remove water, and the polycondensation reaction is carried out for about not less than 10 hours.

8. A method as claimed in claim 6, wherein the weight-average molecular weight of the resulting copolymer is about 5,000 to 30,000.

9. A method as climed in claim 6, wherein the copolymer ratio is about 50 to 95 weight % of lactic acid and about 50 to 5 weight % of glycolic acid.

10. A method as claimed in claim 6, wherein the copolymer ratio is about 60 to 95 weight % of lactic acid and about 40 to 5 weight % of glycolic acid.

11. A method as claimed in claim 6, wherein the copolymer ratio is about 60 to 85 weight % of lactic acid and about 40 to 15 weight % of glycolic acid.

12. A method as claimed in claim 6, wherein the copolymer ratio is about 75.+-.2 mol % of lactic acid and about 25.+-.2 mol % of glycolic acid.
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