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Last Updated: March 28, 2024

Claims for Patent: 4,659,716


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Summary for Patent: 4,659,716
Title: Antihistaminic 8-(halo)-substituted 6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin es
Abstract:Disclosed are 7- and/or 8-(halo or trifluoromethyl)-substituted-6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5 ,6]cyclohepta[1,2-b]pyridines and the pharmaceutically acceptable salts thereof, which possess antihistaminic properties with substantially no sedative properties. Methods for preparing and using the compounds and salts are described.
Inventor(s): Villani; Frank J. (Fairfield, NJ), Wong; Jesse K. (Union, NJ)
Assignee: Schering Corporation (Madison, NJ)
Application Number:06/838,974
Patent Claims: 1. A compound of the formula ##STR17## or a pharmaceutically acceptable salt thereof, wherein X represents Cl or F.

2. A compound defined in claim 1 in the form of the acetic acid salt.

3. A compound having the structural formula ##STR18## or a pharmaceutically acceptable salt thereof.

4. A compound having the structural formula ##STR19## or a pharmaceutically acceptable salt thereof.

5. An antihistaminic pharmaceutical composition which comprises an antihistaminic effective amount of a compound as defined in claim 1 in combination with a pharmaceutically acceptable carrier.

6. An antihistaminic pharmaceutical composition which comprises an antihistaminic effective amount of the compound defined in claim 2 in combination with a pharmaceutically acceptable carrier.

7. An antihistaminic pharmaceutical composition which comprises an antihistaminic effective amount of the compound defined in claim 3 in combination with a pharamaceutically acceptable carrier.

8. An antihistaminic pharmaceutical composition which comprises an antihistaminic effective amount of the compound defined in claim 4 in combination with a pharmaceutically acceptable carrier.

9. A composition as defined in claim 7 in unit dosage form.

10. A composition as defined in claim 8 in unit dosage form.

11. A transdermally acceptable pharmaceutical composition comprising an anti-allergic effective amount of a compound as defined in claim 1 and a pharamaceutically acceptable transdermal carrier.

12. A transdermally acceptable pharamaceutical composition comprising a anti-allergic effective amount of a compound as defined in claim 3 and a pharmaceutically acceptable transdermal carrier.

13. A transdermally acceptable pharmaceutical composition comprising an anti-allergic effective amount of a compound as defined in claim 4 and a pharmaceutically acceptable transdermal carrier.

14. A method for treating allergic reactions in a mammal which comprises administering to said mammal an anti-allergic effective amount of a compound as defined in claim 1.

15. A method of treating allergic reactions in a mammal which comprises administering to said mammal an anti-allergic effective amount of a compound as defined in claim 3.

16. A method for treating allergic reactions in a mammal which comprises administering to said mammal an anti-allergic effective amount of a compound as defined in claim 4.

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