.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 4,650,807

« Back to Dashboard

Claims for Patent: 4,650,807

Title: Antihistaminic compositions and methods containing pyridine derivatives
Abstract:This disclosure describes a compound of Formula I ##STR1## (including its pharmaceutically acceptable salts and esters) which has potent antihistamine activity which is substantially free from sedative effects and which has little or no anticholinergic effects.
Inventor(s): Findlay; John W. A. (Chapel Hill, NC), Coker; Geoffrey G. (Bromley, GB)
Assignee: Burroughs Wellcome Co. (Research Triangle Park, NC)
Application Number:06/753,791
Patent Claims: 1. A method of obtaining an antihistaminic effect in a mammal in need thereof comprising the oral, rectal, topical, nasal, ophthalmic or parenteral administration to said mammal of an effective antihistaminic amount of the compound of formula (I), ##STR10## or a pharmaceutically acceptable salt thereof.

2. The method of claim 1 wherein the mammal is a human.

3. The method of claim 2 wherein the compound of formula (I) is administered as the hydrochloride salt.

4. The method of claim 2 wherein the compound of formula (I) is administered as the sulfate salt.

5. The method of claim 2 wherein the compound of formula (I) is administered as the sodium salt.

6. The method of claim 2 wherein the compound of formula (I) is administered as the potassium salt.

7. The method of claim 2 in which the hydrochloride salt of the compound is orally administered.

8. The method of claim 1 in which the compound is administered orally and the mammal is a human.

9. The method of claim 8 in which the hydrochloride salt is administered.

10. A method of providing an antihistaminic and decongestant effect in a mammal which comprises the oral, rectal, topical, nasal, ophthalmic or parenteral administration to said mammal of a composition comprising an effective antihistaminic amount of (E)-3-(6-(3-pyrrolidino-1-(4-tolyl)prop-1E-enyl)-2-pyridyl)acrylic acid or a pharmaceutically acceptable salt thereof and an effective decongestant amount of pseudoephedrine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier therefor.

11. The method of claim 10 in which a pharmaceutically acceptable salt of (E)-3-(6-(3-pyrrolidino-1-(4-tolyl)prop-1-E-enyl)-2-pyridyl)acrylic acid and a pharmaceutically acceptable salt of pseudoephedrine are administered.

12. The method of claim 1 in which the salts are administered orally.

13. A pharmaceutical composition comprising an effective antihistaminic amount of the compound of formula (I), ##STR11## or a pharmaceutically acceptable salt thereof together with a pharmaceutically acceptable carrier therefor.

14. The composition as claimed in claim 13 in unit dosage form.

15. The composition as claimed in claim 14, in the form of a tablet, syrup, suppository or sterile aqueous preparation.

16. A composition containing 0.25 mg to 20 mg of a compound of formula (I) ##STR12## or a pharmaceutically acceptable salt thereof calculated as the free compound and a pharmaceutically acceptable carrier therefor.

17. The composition according to claim 16 in a capsule.

18. The composition according to claim 16 in the form of a tablet.

19. A composition containing 0.25 mg to 20 mg of a compound of formula (I) ##STR13## or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable liquid carrier therefor.

20. A composition comprising an effective antihistaminic amount of (E)-3-(6-3-pyrrolidino-1-(4-Tolyl)prop-1E-enyl)-2-pyridyl)acrylic acid or a pharmaceutically acceptable salt thereof and an effective decongestant amount of pseudoephedrine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier therefor.

21. The composition of claim 20 comprising an effective antihistaminic amount of a pharmaceutically acceptable salt of (E)-3-(6-(3-pyrrolidino-1-(4-tolyl)prop-1E-enyl)-2-pyridyl)acrylic acid and an effective decongestant amount of a pharmaceutically acceptable salt of psuedophedrine and a pharmaceutically acceptable carrier therefor.

22. A tablet or capsule suitable for oral administration containing an effective antihistaminic amount of the hydrochloride salt of (E)-3-(6-(3-pyrrolidino-1-(4-tolyl)prop-1E-enyl)-2-pyridyl)acrylic acid together with a pharmaceutically acceptable carrier therefor.

23. A pharmaceutical composition containing 0.25 mg to 20 mg of a pharmaceutically acceptable salt of (E)-3-(6-(3-pyrrolidino-1-(4-tolyl)prop-1E-enyl)-2-pyridyl)acrylic acid together with a pharmaceutically acceptable carrier therefor.

24. The composition of claim 23 in which the salt is the hydrochloride salt.

25. A pharmaceutical composition for oral administration containing an effective antihistaminic amount of a pharmaceutically acceptable salt of (E)-3-(6-(3-pyrrolidino-1-(4-tolyl)prop-1E-enyl)-2-pyridylacrylic acid and a pharmaceutically acceptable liquid carrier therefor.

26. The composition of claim 25 in which the salt is the hydrochloride.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc