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Claims for Patent: 4,617,319

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Claims for Patent: 4,617,319

Title: Method of treating multiple sclerosis
Abstract:A method of treating neuroimmunologic diseases such as multiple sclerosis and acute disseminated encephalomyelitis using 1,4-dihydroxy-5,8-bis[[(2-hydroxyethylamino)ethyl]amino]anthraquinone, or a pharmacologically acceptable acid addition salt thereof.
Inventor(s): Kerwar; Suresh S. (Ossining, NY), Sloboda; Adolph E. (New City, NY), Ridge; Susan C. (Valley Cottage, NY)
Assignee: American Cyanamid Company (Stamford, CT)
Application Number:06/744,370
Patent Claims: 1. A method of treating neuroimmunologic diseases in a mammal which comprises administering parenterally to said mammal from about 0.25 to about 0.5 mg per kilogram of body weight per day of a compound selected from 1,4-dihydroxy-5,8-bis[[2-(2-hydroxethylamino)ethyl]amino]-anthraquinone and the pharmacologically acceptable acid addition salts thereof.

2. A method according to claim 1, wherein the compound is 4-dihydroxy-5,8-bis[[2-(2-hydroxyethylamino)ethyl]amino]anthraquinone, dihydrochloride.

3. A method according to claim 1, wherein the compound is administered intraperitoneally.

4. A method according to claim 1, wherein the neuroimmunologic disease is multiple sclerosis.

5. A method according to claim 1, wherein the neuroimmunologic disease is acute disseminated encephalomyelitis.

6. A method of treating neuroimmunologic diseases in mammals which comprises administering parenterally an sufficient amount of 1,4-dihydroxy-5,8-bis[[2-(2-hydroxyethylamino)ethyl]amino]anthraquinone or a pharmacologically acceptable acid addition salt thereof to palliate muscular weakness and paralysis symptomatic of these diseases in said mammals.

7. A method according to claim 6, wherein the neuroimmunologic disease is multiple sclerosis.

8. A method according to claim 6, wherein the neuroimmunologic disease is acute disseminated encephalomyelitis.
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