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Claims for Patent: 4,602,017

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Claims for Patent: 4,602,017

Title: Substituted aromatic compounds
Abstract:The present invention provides compounds of the formula (III): ##STR1## or an acid addition salt thereof, wherein R.sup.6 is chlorine, bromine, iodine, C.sub.1-4 alkyl or trifluoromethyl, or R.sup.6 and R.sup.7 from a --CH.dbd.CH--CH.dbd.CH-- group optionally substituted by a halogen atom or a C.sub.1-4 alkyl or trifluoromethyl group, R.sup.8 is hydrogen, bromine, iodine, C.sub.1-4 alkyl or trifluoromethyl, R.sup.9 is hydrogen, halogen, C.sub.1-4 alkyl or trifluoromethyl, R.sup.10 is hydrogen, methyl or fluorine and R.sup.11 is amino, C.sub.1-10 acylamino or di-substituted aminomethyleneamino provided that, at most, only two of R.sup.7 -R.sup.10 are other than hydrogen and that R.sup.7 -R.sup.10 are not all hydrogen when R.sup.6 is chlorine. Also provided are pharmaceutical compositions containing compounds of the formula (III), the first medical use of compounds of the formula (III), a process for preparing such compounds and intermediates through which this process proceeds.
Inventor(s): Sawyer; David A. (Hayes, Kent, GB2), Baxter; Martin G. (Dartford, Kent, GB2), Miller; Alistair A. (Tonbridge, Kent, GB2)
Assignee:
Application Number:06/583,286
Patent Claims: 1. 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine.

2. A pharmaceutically acceptable salt of 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine.

3. A pharmaceutical composition comprising an effective anticonvulsant amount of 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier therefor.

4. The composition of claim 3 in a form for oral or parenteral administration.

5. The composition of claim 3 in the form of a sterile injectable solution.

6. The composition of claim 3 in the form of a tablet or capsule.

7. A method of treating convulsions in a mammal comprising administering to said mammal an effective anticonvulsant treatment amount of the compound 3,5-Diamino-6-(2,3-dichlorophenyl)1,2,4-triazine or a pharmaceutically acceptable salt thereof.

8. The method of treating convulsions according to claim 7 in which the compound is administered.

9. The method of treating convulsions according to claim 7 in which the compound or salt is administered in a pharmaceutically acceptable carrier in a form suitable for oral or parenteral administration.

10. A method of treating epilepsy in a human comprising administering to said human an effective epilepsy treatment amount of the compound 3,5-Diamino-6-(2,3-dichlorophenyl)1,2,4-triazine or a pharmaceutically acceptable salt thereof.

11. The method of claim 10 in which the compound is administered.

12. The method of claim 10 in which the compound or salt is administered in a pharmaceutically acceptable carrier in a form suitable for oral or parenteral administration.
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