Claims for Patent: 4,602,017

Summary for Patent: 4,602,017

Title:	Substituted aromatic compounds
Abstract:	The present invention provides compounds of the formula (III): ##STR1## or an acid addition salt thereof, wherein R6 is chlorine, bromine, iodine, C1-4 alkyl or trifluoromethyl, or R6 and R7 from a --CH═CH--CH═CH-- group optionally substituted by a halogen atom or a C1-4 alkyl or trifluoromethyl group, R8 is hydrogen, bromine, iodine, C1-4 alkyl or trifluoromethyl, R9 is hydrogen, halogen, C1-4 alkyl or trifluoromethyl, R10 is hydrogen, methyl or fluorine and R11 is amino, C1-10 acylamino or di-substituted aminomethyleneamino provided that, at most, only two of R7 -R10 are other than hydrogen and that R7 -R10 are not all hydrogen when R6 is chlorine. Also provided are pharmaceutical compositions containing compounds of the formula (III), the first medical use of compounds of the formula (III), a process for preparing such compounds and intermediates through which this process proceeds.
Inventor(s):	David A. Sawyer, Martin G. Baxter, Alistair A. Miller
Assignee:	SmithKline Beecham Corp
Application Number:	US06/583,286
Patent Claims:	1. 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine. 2. A pharmaceutically acceptable salt of 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine. 3. A pharmaceutical composition comprising an effective anticonvulsant amount of 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier therefor. 4. The composition of claim 3 in a form for oral or parenteral administration. 5. The composition of claim 3 in the form of a sterile injectable solution. 6. The composition of claim 3 in the form of a tablet or capsule. 7. A method of treating convulsions in a mammal comprising administering to said mammal an effective anticonvulsant treatment amount of the compound 3,5-Diamino-6-(2,3-dichlorophenyl)1,2,4-triazine or a pharmaceutically acceptable salt thereof. 8. The method of treating convulsions according to claim 7 in which the compound is administered. 9. The method of treating convulsions according to claim 7 in which the compound or salt is administered in a pharmaceutically acceptable carrier in a form suitable for oral or parenteral administration. 10. A method of treating epilepsy in a human comprising administering to said human an effective epilepsy treatment amount of the compound 3,5-Diamino-6-(2,3-dichlorophenyl)1,2,4-triazine or a pharmaceutically acceptable salt thereof. 11. The method of claim 10 in which the compound is administered. 12. The method of claim 10 in which the compound or salt is administered in a pharmaceutically acceptable carrier in a form suitable for oral or parenteral administration.