|Title:|| Propranolol hydrochloride liquid formulations|
|Abstract:||Therapeutic liquid oral dosage formulations of propranolol hydrochloride are provided which contain lecithin and/or a basic amino acid to impart taste masking characteristics and/or contain a basic amino acid to impart anesthesia masking characteristics.|
|Inventor(s):|| Reuter; Gerald L. (Plattsburgh, NY), Coons; Mark E. (Champlain, NY) |
|Assignee:|| American Home Products Corporation (New York, NY) |
1. A liquid oral therapeutic dosage form composition of propranolol hydrochloride having satisfactory taste and anesthesia masking characteristics containing for each 10 milligrams per
milliliter of propranolol hydrochloride in such composition about 8 to about 14 precent weight by volume of oil free lecithin and about 0.5 to 10% by weight of at least one basic amino acid.
2. The liquid oral therapeutic dosage form of claim 1 wherein the basic amino acid is L-histidine free base.
3. The liquid oral therapeutic dosage form of claim 1 wherein the basic amino acids are L-arginine free base and L-histidine HCl.
4. The liquid oral therapeutic dosage form of claim 1 wherein the basic amino acids are L-arginine, free base and L-histidine HCl.