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Claims for Patent: 4,600,708

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Claims for Patent: 4,600,708

Title: Propranolol hydrochloride liquid formulations
Abstract:Therapeutic liquid oral dosage formulations of propranolol hydrochloride are provided which contain lecithin and/or a basic amino acid to impart taste masking characteristics and/or contain a basic amino acid to impart anesthesia masking characteristics.
Inventor(s): Reuter; Gerald L. (Plattsburgh, NY), Coons; Mark E. (Champlain, NY)
Assignee: American Home Products Corporation (New York, NY)
Application Number:06/757,213
Patent Claims: 1. A liquid oral therapeutic dosage form composition of propranolol hydrochloride having satisfactory taste and anesthesia masking characteristics containing for each 10 milligrams per milliliter of propranolol hydrochloride in such composition about 8 to about 14 precent weight by volume of oil free lecithin and about 0.5 to 10% by weight of at least one basic amino acid.

2. The liquid oral therapeutic dosage form of claim 1 wherein the basic amino acid is L-histidine free base.

3. The liquid oral therapeutic dosage form of claim 1 wherein the basic amino acids are L-arginine free base and L-histidine HCl.

4. The liquid oral therapeutic dosage form of claim 1 wherein the basic amino acids are L-arginine, free base and L-histidine HCl.
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