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Last Updated: December 16, 2025

Claims for Patent: 4,599,353

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Summary for Patent: 4,599,353

Title:	Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma
Abstract:	Ocular hypertension and glaucoma can be effectively controlled in primates through topical application of an effective amount of an eicosanoid or an eicosanoid derivative to the surface of an afflicted eye. Eicosanoids, particularly the prostaglandins PGE2 and PGF2α, and derivatives thereof, have been found effective in quantities less than about 1000 μg per eye. Ophthalmic compositions containing C1 to C5 alkyl esters of PGF2α are presently preferred for use in treating ocular hypertension and glaucoma in primates, including man.
Inventor(s):	Laszlo Z. Bito
Assignee:	Columbia University in the City of New York
Application Number:	US06/374,165
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 4,599,353
Patent Claims:

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