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Claims for Patent: 4,567,182

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Claims for Patent: 4,567,182

Title: Compounds endowed with immunomodulating activity
Abstract:The invention relates to a series of purine derivatives of formula (I) ##STR1## wherein R is hydrogen or NH.sub.2, n is an integer from 1 to 6, R.sup.1 is one of the following chains: ##STR2## wherein R.sup.2 is the residue of an aminoacid, R.sup.3 is hydrogen or the residue of an oligopeptide and R.sup.4 is OH or the residue of an oligopeptide.
Inventor(s): Ferraris; Paolo C. (Genoa, IT)
Assignee: Co Pharma Corporation s.r.l. (Genoa, IT)
Application Number:06/418,189
Patent Claims: 1. A compound of formula I ##STR22## wherein: R is hydrogen or NH.sub.2 ;

n is an integer from 1 to 6;

R.sub.1 is a chain of formula ##STR23## wherein R.sub.2 is the radical attached to the .alpha.-carbon atom of an .alpha.-aminoacid of formula ##STR24## said aminoacid being glycine, alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, glutamic acid, arginine, lysine, cysteine, cystine, methionine, phenylalanine, tyrosine, tryptophan, proline or histidine;

R.sub.3 is hydrogen; p1 m and p are integers ranging independently from 2 to 6,

A is a group of formula ##STR25## wherein R.sub.2 is as indicated hereinabove,

R.sub.4 is OH or

A is a group of formula ##STR26## wherein R.sub.4 is as indicated hereinabove.

2. Compounds of claim 1, in which each .alpha.-amino acid is in laevorotatory, dextrorotatory or racemic form.

3. Compounds of claim 1, in which each amino acid is a natural amino acid.

4. A pharmaceutical composition with immunomodulator activity, which comprises one or more compounds of formula (I), according to claim 1 and at least one inert carrier.

5. A compound of formula IX ##STR27## wherein: n is an integer number between 2 and 6;

r is between 0 and 2;

s is 1;

R.sup.6 is a member selected from the group consisting of ##STR28## R is H.

6. A pharmaceutical composition with immunomodulator activity, according to claim 4 wherein said compound has formula IX ##STR29## wherein: n is an integer number between 2 and 6;

r is between 0 and 2;

s is 1;

R.sup.6 is a member selected from the group consisting of ##STR30## R is H.

7. The compound according to claim 1 of formula ##STR31##

8. A compound according to claim 5 of formula P'--CH.sub.2 --CH.sub.2 --O--CO--CH.sub.2 --CH.sub.2 --CO--NH--CH.sub.2 --COOH, wherein P' is ##STR32##

9. The compound according to claim 5 of formula ##STR33##

10. The compound according to claim 5 of formula ##STR34##

11. The compound according to claim 5 of formula ##STR35##

12. The compound according to claim 5 of formula ##STR36##

13. The compound according to claim 5 of formula ##STR37##

14. The compound according to claim 5 of formula ##STR38##
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