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Claims for Patent: 4,562,060

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Claims for Patent: 4,562,060

Title: Local anesthetic mixture for topical application, process for its preparation, as well as method for obtaining local anesthesia
Abstract:The present invention relates to pharmacological active preparations, especially local anesthetic preparations and deals with the problem of i a obtaining a solution of a local anesthetic agent in the form of its base, where the concentration is higher than otherwise possible. This problem has been dissolved according to the present invention thereby that one local anesthetic agent in the form of its base and as such having a melting point of 30.degree. to 50.degree. C., preferably prilocaine or tetracaine, is provided with one other local anesthetic agent in the form of its base and as such having a melting point of above 30.degree. C., preferably above 40.degree. C., preferably bensocaine, lidocaine, bupivacaine, mepivacaine, etidocaine or tetracaine which agents when brought and heated together form a homogenous oil having a melting of preferably below 40.degree. C., more preferably below 25.degree. C.
Inventor(s): Broberg; Berndt F. J. (Sodertalje, SE), Evers; Hans C. A. (Sodertalje, SE)
Assignee: Astra Lakemedel Aktiebolag (SE)
Application Number:06/684,458
Patent Claims: 1. A locally active anesthetic agent comprising paper embedded with a homogeneous oil which is useful for topical application, consisting essentially of prilocaine in the form of its base in admixture with lidocaine, in the form of its base in a weight ratio of 42:58 to 80:20 such that the resulting mixture is a homogeneous oil which has a melting point of below 40.degree. C.

2. A method of obtaining local anesthesia in mammals by way of topical application, which comprises administering to a patient a paper embedded with an anesthetically effective amount of a combination of prilocaine in the form of its base in admixture with lidocaine in the form of its base in a weight ratio of 42:58 to 80:20 such that the resulting mixture is a homogeneous oil which has a melting point of below 40.degree. C.
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