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Last Updated: December 12, 2025

Claims for Patent: 4,559,222

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Summary for Patent: 4,559,222

Title:	Matrix composition for transdermal therapeutic system
Abstract:	Mineral oil (MO) polyisobutylene (PIB), colloidal silicon dioxide (CSD) mixtures suitable for use as drug containing matrices in transdermal delivery systems are disclosed. Preferred systems for dispensing moderately mineral oil soluble drugs contain at least about 6% CSD, have a MO/PIB of at least 1.0 and a viscosity of at least 1.5x107 poises. Preferred systems for dispensing clonidine have a clonidine permeability of at least 1.0x10-4 mu g/cm sec and a MO/PIB of at least 1.2.
Inventor(s):	David J. Enscore, Robert M. Gale
Assignee:	Alza Corp
Application Number:	US06/491,490
Patent Claims:

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