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Claims for Patent: 4,552,899

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Claims for Patent: 4,552,899

Title: Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs
Abstract:Pharmaceutical compositions and methods of using same comprising a non-steroidal anti-inflammatory drug in combination with at least one other active component selected from an antihistamine, decongestant, cough suppressant (antitussive) or expectorant are provided for the relief of cough, cold and cold-like symptoms.
Inventor(s): Sunshine; Abraham (New York, NY), Laska; Eugene M. (Larchmont, NY), Siegel; Carole E. (Mamaroneck, NY)
Assignee: Analgesic Associates (Larchmont, NY)
Application Number:06/598,502
Patent Claims: 1. A pharmaceutical composition of matter for use in the treatment of cough, cold, cold-like and/or flu symptoms in a mammalian organism, said composition comprising a sympathomimetically, analgesically and anti-inflammatorily effective amount of (i) at least one of the propionic acid NSAIDs, ibuprofen, naproxen, benozaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, pranoprofen, miroprofen, trioxaprofen, suprofen, alminoprofen, tiaprofenic acid, fluprofen, bucloxic acid, or pharmaceutically acceptable salt thereof, in combinatory immixture with (ii) at least one of the sympathomimetic amines, pseudoephedrine, phenylpropanolamine, phenylephrine, or pharmaceutically acceptable salt thereof.

2. The pharmaceutical composition as defined by claim 1, said NSAID (i) comprising ibuprofen, naproxen, flurbiprofen, fenoprofen, ketoprofen, suprofen, fenbufen, fluprofen, or pharmaceutically acceptable salt thereof.

3. The pharmaceutical composition as defined by claim 2, said NSAID (i) comprising ibuprofen or pharmaceutically acceptable salt thereof.

4. The pharmaceutical composition as defined by claim 2, said NSAID (i) comprising naproxen or pharmaceutically acceptable salt thereof.

5. The pharmaceutical composition as defined by claim 1, comprising at least 25 mg of said NSAID (i).

6. The pharmaceutical composition as defined by claim 5, comprising from 25 mg to 600 mg of said NSAID (i).

7. The pharmaceutical composition as defined by claim 3, comprising from 50 mg to 400 mg of ibuprofen or pharmaceutically acceptable salt thereof.

8. The pharmaceutical composition as defined by claim 7, comprising at least 100 mg of ibuprofen or pharmaceutically acceptable salt thereof.

9. The pharmaceutical composition as defined by claim 4, comprising from 125 mg to 500 mg of naproxen or pharmaceutically acceptable salt thereof.

10. The pharmaceutical composition as defined by claim 5, comprising (ii) from 60 mg to 120 mg of pseudoephedrine or pharmaceutically acceptable salt thereof.

11. The pharmaceutical composition as defined by claim 5, comprising (ii) from 25 mg to 50 mg of phenylpropanolamine or pharmaceutically acceptable salt thereof.

12. The pharmaceutical composition as defined by claim 5, comprising (ii) from 5 mg to 25 mg of phenylephrine or pharmaceutically acceptable salt thereof.

13. The pharmaceutical composition as defined by claim 1, further comprising (iii) a pharmaceutically acceptable non-toxic carrier.

14. The pharmaceutical composition as defined by claim 1, in oral dosage form.

15. The pharmaceutical composition as defined by claim 14, said oral dosage form comprising a tablet.

16. The pharmaceutical composition as defined by claim 14, said oral dosage form comprising a capsule.

17. The pharmaceutical composition as defined by claim 14, said oral dosage form comprising an elixir.

18. A method for the treatment of cough, cold, cold-like and/or flu symptoms in a mammalian organism in need of such treatment, comprising administering to such organism a symptom relieving, sympathomimetically, analgesically and anti-inflammatorily effective amount of (i) at least one of the propionic acid NSAIDs, ibuprofen, naproxen, benozaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, pranoprofen, miroprofen, trioxaprofen, suprofen, alminoprofen, tiaprofenic acid, fluprofen, bucloxic acid, or pharmaceutically acceptable salt thereof, in combinatory immixture with (ii) at least one sympathomimetic decongestant or bronchodilator, or pharmaceutically acceptable salt thereof.

19. A method for the treatment of cough, cold, cold-like and/or flu symptoms in a mammalian organism in need of such treatment, comprising administering to such organism the pharmaceutical composition as defined by claim 1.

20. A method for the treatment of cough, cold, cold-like and/or flu symptoms in a mammalian organism in need of such treatment, comprising administering to such organism the pharmaceutical composition as defined by claim 13.
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