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Claims for Patent: 4,539,333

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Claims for Patent: 4,539,333

Title: Prostacyclin, methods of using and method of making
Abstract:Prostacyclin, its salts, biosynthesis and synthesis thereof, pharmaceutical formulations containing them, and their use in medicine.
Inventor(s): Moncada; Salvador (West Wickham, GB2)
Assignee: Burroughs Wellcome Co. (Research Triangle Park, NC)
Application Number:06/795,524
Patent Claims: 1. Prostacyclin substantially free from other biological material.

2. The method of treating thrombosis in a mammal which comprises administering an effective antithrombotic portion of prostacyclin to said mammal in need thereof.

3. The method of inhibiting the aggregation of blood platelets in a mammal which comprises administering an effective platelet antiaggregation amount of prostacyclin to said mammal.

4. A method of preventing thrombosis in a mammal in need thereof which comprises administering an effective thrombosis prevention amount of prostacyclin to said mammal.

5. A method for the prevention or treatment of gastric lessions in a mammal comprising the administration of a non-toxic prevention or treatment amount of prostacylin to said mammal.

6. A method for the treatment of a wound in a mammal which comprises administering to said mammal a non-toxic wound treatment amount of prostacylin.

7. A method for producing a vasodilatory action in the blood vessels of a mammal in need thereof comprising the administration of an effective vasodilatory amount of prostacyclin to said mammal.

8. The method of preparing (5-Z)-5,6-Didehydro-9-deoxy-6,9.alpha.-epoxyprostaglandin F.sub.1.alpha. which comprises incubating microsomes of mammalian tissue with a prostaglandin endoperoxide.

9. The method of claim 8 in which the microsomes are aortic microsomes and the prostaglandin endoperoxides are PGG.sub.2 or PGH.sub.2.
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