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Last Updated: December 12, 2025

Claims for Patent: 4,537,883

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Summary for Patent: 4,537,883

Title:	Lyophilized cyclophosphamide
Abstract:	A lyophilized pharmaceutical solid composition containing cyclophosphamide for reconstitution with water to provide a solution for oral or parenteral administration. This lyophilized cyclophosphamide solid composition demonstrates improved stability, solubility characteristics and enhanced appearance compared with currently available dry powder pre-mix compositions of cyclophosphamide. The lyophilized solid composition contains about 20 parts by weight of cyclophosphamide, about 11/4-2 parts by weight of water and from about 10-85 parts by weight of excipient which is comprised mainly of mannitol. Processes for making the composition are disclosed.
Inventor(s):	Robert L. Alexander, Robert J. Bequette, Terry T. Kensler, Joseph A. Scott
Assignee:	Mead Johnson and Co LLC
Application Number:	US06/589,202
Patent Claims:

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