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Claims for Patent: 4,536,516

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Claims for Patent: 4,536,516

Title: Alkene derivatives
Abstract:Triphenylalkene derivatives, in particular 1-(p-.beta.-dimethylaminoethyoxyphenyl)-1,2-diphenylbut-1-ene, which possess utility as anti-oestrogens.
Inventor(s): Harper; Michael J. K. (Ferney-Voltaire, FR), Richardson; Dora N. (Macclesfield, GB2), Walpole, deceased; Arthur L. (Macclesfield, GB2)
Assignee: Imperial Chemical Industries PLC (London, GB2)
Application Number:06/600,224
Patent Claims: 1. The geometric isomer of 1-(p-.beta.-dimethylaminoethoxyphenyl)-1,2-diphenylbut-1ene, and the pharmaceutically acceptable, acid addition salts thereof, which is identified by its citrate having a melting point of 140.degree.-142.degree. C.

2. 1-(p-.beta.-dimethylaminoethoxyphenyl)-trans-1,2-diphenylbut-1-ene and the pharmaceutically acceptable, acid addition salts thereof.

3. 1-(p-.beta.-dimethylaminoethoxyphenyl)-1,2-diphenylbut-1-ene citrate of melting point 140.degree.-142.degree. C.

4. In a process for the treatment of hormone dependent tumors, the improvement which comprises treating said tumors with an effective amount of a member of the group consisting of the geometric isomer of 1-(p-.beta.-dimethylaminoethoxyphenyl)-1,2-diphenylbut-1-ene, and the pharmaceutically acceptable, acid addition salts thereof, which isomer is identified by its citrate having a melting point of 140.degree.-142.degree. C.

5. In a process for the treatment of hormone dependent tumors, the improvement which comprises treating said tumors with an effective amount of a member selected from the group consisting of 1-(p-.beta.-dimethylaminoethoxyphenyl)-trans-1,2-diphenylbut-1-ene and the pharmaceutically acceptable, acid addition salts thereof.

6. In a process for the treatment of hormone dependent tumors, the improvement which comprises treating said tumors with an effective amount of 1-(p-.beta.-dimethylaminoethoxyphenyl)-1,2-diphenylbut-1-ene citrate of melting point 140.degree.-142.degree. C.
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