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Claims for Patent: 4,536,386

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Claims for Patent: 4,536,386

Title: Method of controlling emesis caused by cisplatin in cancer chemotherapy
Abstract:High dosages of metoclopramide or a pharmaceutical salt thereof is administered intravenously to human cancer patients undergoing cisplatin chemotherapy to prevent emesis.
Inventor(s): Keenan; Robert E. (Richmond, VA)
Assignee: A. H. Robins Company, Inc. (Richmond, VA)
Application Number:06/508,367
Patent Claims: 1. A method for alleviating emesis in human cancer patients caused by cisplatin chemotherapy which comprises administering about 5 to 18 mg of metoclopramide or a pharmaceutically acceptable salt thereof per kg of patient body weight over a period of time spanning about 30 minutes prior to cisplatin administration through the post administration period, said metoclopramide or the pharmaceutically acceptable salt thereof being administered either continuously or as 4 to 7 individually spaced dosages about 11/2 to 3 hours apart.

2. The method of claim 1 wherein the metoclopramide or a pharmaceutically acceptable salt thereof is administered intraveneously in the presence of a liquid carrier therefor.

3. The method of claim 1 wherein the metoclopramide or a pharmaceutically acceptable salt thereof is divided into 4 to 7 individually spaced dosages which are administered about 11/2 to 3 hours apart.

4. The method of claim 3 wherein the amount of cisplatin administered is about 100 mg/square meter or less of patient body surface and each of the individually spaced dosages are comprised of about 1 mg contained metoclopramide per kg of body weight.

5. The method of claim 3 wherein the amount of cisplatin administered is at or above about 120 mg/square meter of patient body surface and each of the individually spaced dosages are comprised of about 2-3 mg contained metoclopramide per kg of body weight.

6. The method of claim 1 wherein the monohydrochloride monohydrate salt of metoclopramide is used

7. The method of claim 1 wherein the metoclopramide or a pharmaceutically acceptable salt thereof is administered as a continuous infusion.
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