Claims for Patent: 4,526,892

Summary for Patent: 4,526,892

Title:	Dimethylaminoalkyl-3-(ergoline-8'βcarbonyl)-ureas
Abstract:	Novel ergoline derivatives formed by reaction of an 8-carboxy ergoline with a carbodiimide and having hypotensive and antiprolatinic activity.
Inventor(s):	Patricia Salvati, Anna M. Caravaggi, Aldemio Temperilli, Germano Bosisio, Osvaldo Sapini, Enrico DI Salle
Assignee:	Pfizer Italia SRL
Application Number:	US06/448,364
Patent Claims:	1. Compounds of formula ##STR3## wherein R1 is a hydrogen atom or a methyl group; R2 is a hydrogen atom; R3 is a hydrogen atom or a methoxy group; R4 is an alkyl or an alkenyl group selected from methyl, allyl and propyl groups; and each of R5 and R6 independently is an alkyl group having from 1 to 3 carbon atoms or a group of the formula (CH2)n N(CH3)2 in which n is 3 with the proviso that at least one of R5 and R6 is said dimethylaminoalkyl group, and pharmaceutically acceptable addition salts with organic or inorganic acid thereof. 2. A compound according to claim 1 which is selected from the group consisting of:1-ethyl-3-(3'-dimethylaminopropyl)-3(6'-methylergoline-8'β-carbonyl)-urea; 1-ethyl-3-(3'-dimethylaminopropyl)-3-(10'α-methoxy-6'-methylergoline-8'β-carbonyl)-urea; 1-(3'-dimethylaminopropyl)-3-ethyl-3-(6'-allylergoline-8'β-carbonyl)-urea; and 1-ethyl-3-(3'-dimethylaminopropyl)-3-(6'-n-propylergoline-8'β-carbonyl)-urea. 3. A pharmaceutical composition containing a therapeutically effective amount of a compound according to claim 1, in admixture with a pharmaceutically acceptable carrier for oral or parenteral administration. 4. 1-ethyl-3-(3'dimethylaminopropyl)-3-(6'-allylergoline-8'β-carbonyl)-urea.