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Serving leading biopharmaceutical companies globally:

Express Scripts
Chinese Patent Office
Daiichi Sankyo
Covington
UBS
Argus Health
Julphar
US Army
Dow
Johnson and Johnson

Generated: January 19, 2018

DrugPatentWatch Database Preview

Claims for Patent: 4,526,892

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Summary for Patent: 4,526,892
Title: Dimethylaminoalkyl-3-(ergoline-8'.beta.carbonyl)-ureas
Abstract:Novel ergoline derivatives formed by reaction of an 8-carboxy ergoline with a carbodiimide and having hypotensive and antiprolatinic activity.
Inventor(s): Salvati; Patricia (Milan, IT), Caravaggi; Anna M. (Milan, IT), Temperilli; Aldemio (Milan, IT), Bosisio; Germano (Milan, IT), Sapini; Osvaldo (Gallarate, IT), di Salle; Enrico (Milan, IT)
Assignee: Farmitalia Carlo Erba, S.p.A. (Milan, IT)
Application Number:06/448,364
Patent Claims: 1. Compounds of formula ##STR3## wherein R.sub.1 is a hydrogen atom or a methyl group; R.sub.2 is a hydrogen atom; R.sub.3 is a hydrogen atom or a methoxy group; R.sub.4 is an alkyl or an alkenyl group selected from methyl, allyl and propyl groups; and each of R.sub.5 and R.sub.6 independently is an alkyl group having from 1 to 3 carbon atoms or a group of the formula (CH.sub.2).sub.n N(CH.sub.3).sub.2 in which n is 3 with the proviso that at least one of R.sub.5 and R.sub.6 is said dimethylaminoalkyl group, and pharmaceutically acceptable addition salts with organic or inorganic acid thereof.

2. A compound according to claim 1 which is selected from the group consisting of:

1-ethyl-3-(3'-dimethylaminopropyl)-3(6'-methylergoline-8'.beta.-carbonyl)-u rea;

1-ethyl-3-(3'-dimethylaminopropyl)-3-(10'.alpha.-methoxy-6'-methylergoline- 8'.beta.-carbonyl)-urea;

1-(3'-dimethylaminopropyl)-3-ethyl-3-(6'-allylergoline-8'.beta.-carbonyl)-u rea; and

1-ethyl-3-(3'-dimethylaminopropyl)-3-(6'-n-propylergoline-8'.beta.-carbonyl )-urea.

3. A pharmaceutical composition containing a therapeutically effective amount of a compound according to claim 1, in admixture with a pharmaceutically acceptable carrier for oral or parenteral administration.

4. 1-ethyl-3-(3'dimethylaminopropyl)-3-(6'-allylergoline-8'.beta.-carbonyl) -urea.

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Serving leading biopharmaceutical companies globally:

Accenture
Baxter
Federal Trade Commission
Mallinckrodt
Teva
Farmers Insurance
Fuji
Harvard Business School
Covington

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