Generated: April 23, 2017
|Abstract:||Novel ergoline derivatives formed by reaction of an 8-carboxy ergoline with a carbodiimide and having hypotensive and antiprolatinic activity.|
|Inventor(s):||Salvati; Patricia (Milan, IT), Caravaggi; Anna M. (Milan, IT), Temperilli; Aldemio (Milan, IT), Bosisio; Germano (Milan, IT), Sapini; Osvaldo (Gallarate, IT), di Salle; Enrico (Milan, IT)|
|Assignee:||Farmitalia Carlo Erba, S.p.A. (Milan, IT)|
1. Compounds of formula ##STR3## wherein R.sub.1 is a hydrogen atom or a methyl group; R.sub.2 is a hydrogen atom; R.sub.3 is a hydrogen atom or a methoxy group; R.sub.4 is
an alkyl or an alkenyl group selected from methyl, allyl and propyl groups; and each of R.sub.5 and R.sub.6 independently is an alkyl group having from 1 to 3 carbon atoms or a group of the formula (CH.sub.2).sub.n N(CH.sub.3).sub.2 in which n is 3 with
the proviso that at least one of R.sub.5 and R.sub.6 is said dimethylaminoalkyl group, and pharmaceutically acceptable addition salts with organic or inorganic acid thereof.
2. A compound according to claim 1 which is selected from the group consisting of:
1-(3'-dimethylaminopropyl)-3-ethyl-3-(6'-allylergoline-8'.beta.-carbonyl)-u rea; and
3. A pharmaceutical composition containing a therapeutically effective amount of a compound according to claim 1, in admixture with a pharmaceutically acceptable carrier for oral or parenteral administration.
4. 1-ethyl-3-(3'dimethylaminopropyl)-3-(6'-allylergoline-8'.beta.-carbonyl) -urea.