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Claims for Patent: 4,508,729

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Claims for Patent: 4,508,729

Title: Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
Abstract:Compounds of the general formula: ##STR1## wherein: the ring A is saturated and n=0 or 1, or the ring A is a benzene ring and n=1, R.sub.1 represents a lower alkyl group which can carry an amino group, R.sub.2 represents a hydrogen atom or a lower alkyl group, R.sub.3 represents a straight or branched alkyl group, a mono- or di-cycloalkylalkyl or phenylalkyl group having no more than a total of 9 carbon atoms, or a substituted alkyl group, and also the salts thereof. These compounds are useful as therapeutic drugs.
Inventor(s): Vincent; Michel (Bagneux, FR), Remond; Georges (Versailles, FR), Laubie; Michel (Vaucresson, FR)
Assignee: Adir (Neuilly-sur-Seine, FR)
Application Number:06/308,234
Patent Claims: 1. A compound selected from the group consisting of iminodiacid compounds having the formula: ##STR20## wherein R.sub.1 represents lower-alkyl having 1 to 4 carbon atoms, inclusive,

R.sub.2 represents hydrogen or lower-alkyl having 1 to 4 carbon atoms, inclusive,

R.sub.3 is --CH.sub.2 CH.sub.2 --CH.sub.3, in racemic form or as an optical isomer, a salt thereof with a pharmaceutically-acceptable inorganic or organic base, and an addition salt thereof with a pharmaceutically-acceptable inorganic or organic acid.

2. A compound of claim 1, in which R.sub.1 is a methyl radical.

3. (2S)-1-{N[(1RS)-1-ethoxycarbonylbutyl]-(S)-alanyl}-2-carboxy perhydroindole, its (S)-isomer or the sodium salt of these.

4. A pharmaceutical composition containing as active ingredient at least one compound according to claim 1, in conjunction with an inert, non-toxic pharmaceutically-acceptable carrier or excipient.

5. A pharmaceutical composition containing as active ingredient a compound according to claim 3, in conjunction with an inert, non-toxic pharmaceutically-acceptable carrier or excipient.

6. A method for treating a patient suffering from hypertension, which comprises administering to said patient a therapeutically effective dose of a compound according to claim 1.

7. A method for treating a patient suffering from hypertension, which comprises administering to said patient a therapeutically-effective dose of a compound according to claim 3.
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