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Claims for Patent: 4,508,726

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Claims for Patent: 4,508,726

Title: Treatment of panic disorders with alprazolam
Abstract:Therapeutic process for treating panic disorders in humans comprising, the systemic administration of a 1-methyl-6-phenyl-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine including the N-oxides and pharmacologically acceptable acid addition salts thereof in combination with a pharmaceutical carrier.
Inventor(s): Coleman; James H. (Cumberland, RI)
Assignee: The Upjohn Company (Kalamazoo, MI)
Application Number:06/518,332
Patent Claims: 1. A process for preventing or treating panic attacks comprising the administration to a human subject susceptible to panic attacks, in unit dosage form, from about 0.01 mg to about 0.4 mg/kg body weight of 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine or the pharmacologically acceptable acid addition salt or a (5) N-oxide thereof in association with a pharmaceutical carrier.

2. The process of claim 1 wherein the 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine is in the form of the (5) N-oxide.

3. The process of claim 1 wherein the 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine is in the form of the free base.
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