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Claims for Patent: 4,482,539

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Claims for Patent: 4,482,539

Title: Betamethasone dipropionate cream
Abstract:Disclosed is an elegant cream-like formulation of betamethasone dipropionate useful as a topical antiinflammatory product.
Inventor(s): Sandweiss; Varda E. (Forest Hills, NY), Stupak; Elliot (West Caldwell, NJ), Shapiro; Paul H. (West Caldwell, NJ)
Assignee: Schering Corporation (Madison, NJ)
Application Number:06/494,214
Patent Claims: 1. A topical pharmaceutical composition for the treatment of inflammation consisting essentially of 0.02 to 0.10 percent betamethasone dipropionate; 0.4 to 0.6 percent titanium dioxide; 1.0 to 2.5 percent Carbomer 940; sufficient base to adjust the pH to between pH 4.0 to pH 5.5; and about 60 to 80 percent of propylene glycol and about 20 to 40 percent water.

2. A pharmaceutical composition according to claim 1 wherein Carbomer 940 is present in an amount of about 2% by weight.

3. A pharmaceutical composition according to claim 1 consisting essentially of 0.06 to 0.08 percent betamethasone dipropionate; about 0.4 to 0.6 percent titanium dioxide; about 1.0 to 2.5 percent Carbomer 940; sufficient base to adjust the pH to between pH 4.0 to pH 5.5; and about 65 to 75 percent of propylene glycol and about 25 to 35 percent water.

4. A pharmaceutical composition according to claim 1 wherein said base is sodium hydroxide.
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