.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 4,462,983

« Back to Dashboard

Claims for Patent: 4,462,983

Title: Certain ergot peptide alkaloids administered to the nasal mucosa
Abstract:The present invention provides a nasal or pulmonary pharmaceutical composition comprising as active agent a compound of formula I, ##STR1## wherein R.sub.1 is hydrogen or halogen, R.sub.2 is hydrogen or alkyl of 1 to 4 carbon atoms, either (i) R.sub.3 is isopropyl, sec-butyl, or isobutyl, R.sub.4 methyl, ethyl or isopropyl and R.sub.5 is hydrogen and R.sub.6 is hydrogen or methoxy or R.sub.5 and R.sub.6 are together a single bond, or (ii) R.sub.3 is benzyl, R.sub.4 is methyl, R.sub.5 is hydrogen and R.sub.6 is hydrogen or methoxy, or (III) dihydroergocristine, in association with a pharmaceutically acceptable carrier or diluent, adapted for nasal or pulmonary administration.
Inventor(s): Azria; Moise (Paris, FR), Cavanak; Thomas (Oberwil, CH)
Assignee: Sandoz Ltd. (Basel, CH)
Application Number:06/328,680
Patent Claims: 1. An improved method of systemically administering a pharmaceutically effective amount of an ergot peptide alkaloid active agent of formula I, ##STR3## wherein R.sub.1 is hydrogen or halogen,

R.sub.2 is hydrogen, methyl or isopropyl,

either (i)

R.sub.3 is isopropyl, sec-butyl or isobutyl,

R.sub.4 is methyl, ethyl or isopropyl, and

R.sub.5 is hydrogen and R.sub.6 is hydrogen or methoxy

or R.sub.5 and R.sub.6 are together a single bond,

or (ii)

R.sub.3 is benzyl, R.sub.4 is methyl, R.sub.5 is hydrogen and R.sub.6 is hydrogen or methoxy, or (III) dihydroergocristine,

or a pharmaceutically acceptable acid addition salt thereof, the improvement which comprises locally administering to the nasal mucous membranes a therapeutically effective amount of the ergot peptide alkaloid active agent.

2. A method as claimed in claim 1 wherein the compound of formula I is dihydroergotamine.

3. A method as claimed in claim 1 wherein the compound of formula I is bromocriptine.

4. A method as claimed in claim 1 wherein the compound of formula I is dihydroergotoxine.

5. A method as claimed in claim 1 wherein the ergot alkaloid active agent is administered in the form of a spray.

6. A method as claimed in claim 5 wherein an atomiser containing a propellant produces the spray.

7. A method as claimed in claim 6 wherein the propellant is a halogenated hydrocarbon.

8. A method as claimed in claim 5 wherein 0.1 to 5 mg of the ergot peptide alkaloid active agent is administered per administration.

9. A method as claimed in claim 5 wherein the spray is a powder spray.

10. A method as claimed in claim 5 wherein the spray is a liquid spray.

11. A method as claimed in claim 5 wherein the spray is produced from a solution of the ergot peptide alkaloid active agent containing 0.1 to 5 mg of active agent per ml of solution.

12. A method as claimed in claim 1 wherein the active agent is in the form of a pharmaceutically acceptable acid addition salt.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc