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Claims for Patent: 4,454,152

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Claims for Patent: 4,454,152

Title: Methoxsalen dosage forms
Abstract:This invention relates to oral dosage forms wherein the active ingredient, methoxsalen, is dispersed in a water-soluble composition containing a polyethylene glycol or mixtures of polyethylene glycols. Dissolution of methoxsalen in gastrointestinal fluids as well as drug absorption are more rapid and higher blood level patterns are achieved with these dosage forms as compared to conventional encapsulated dosage forms.
Inventor(s): Barry; Richard H. (Bloomfield, NJ), Lazarus; Jack H. (Jersey City, NJ)
Assignee: Hoffmann-La Roche Inc. (Nutley, NJ)
Application Number:06/332,982
Patent Claims: 1. A method of treating a subject afflicted with psoriasis or vitiligo which method comprises

(a) administering to the subject an oral dosage composition comprising a solution of an amount of methoxsalen effective for the treatment of psoriasis or vitiligo in about 10 to about 97.5 percent by weight based on the total weight of the composition of a polyethylene glycol or a mixture of polyethylene glycols which polyethylene glycol or mixture is fluid at room temperature contained within a capsule.

(b) waiting a sufficient time to obtain a peak blood level of methoxsalen in the subject, and

(c) irradiating the subject with ultraviolet light.

2. An oral dosage composition in a unit dosage form comprising a solution of an amount of methoxsalen effective for the treatment of psoriasis or vitiligo in about 10 to about 97.5 percent by weight based on the total weight of the composition of a polyethylene glycol or a mixture of polyethylene glycols which polyethylene glycol or mixture is fluid at room temperature contained within a capsule.

3. An oral dosage composition in unit dosage form comprising a solution, which in percent by weight based on the total weight of the composition, is from about 0.025% to about 10.5% of methoxsalen and from about 10% to about 97.5% of a polyethylene glycol or a mixture of polyethylene glycols which polyethylene glycol or mixture is fluid at room temperature, contained within a capsule.
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