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Last Updated: December 30, 2025

Claims for Patent: 4,442,101

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Summary for Patent: 4,442,101

Title:	Sesquihydrate of naphthyridine derivative, and process for the preparation thereof
Abstract:	Novel 1-ethyl-6-fluoro-1,4-dihyono-4-oxo -7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid.sesquihydrate (ATT-2266.sesquihydrate). The aforesaid compound can be prepared by heating 1-ethyl-6-fluoro-1,4-dihydro-4-oxo -7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid at a temperature above about 60° C. in the presence of water in an amount sufficient to form the sesquihydrate. This sesquihydrate is much more stable than the anhydrate and the trihydrate and is superior to the anhydrate in the rate of dissolution and transference into the body through the intestines. Thus, it is especially useful as a pharmaceutical compound.
Inventor(s):	Hitoshi Ichihashi, Terukazu Tanaka, Yu Imasato
Assignee:	Laboratoire Roger Bellon SA, Sumitomo Pharma Co Ltd
Application Number:	US06/345,916
Patent Claims:

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