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Claims for Patent: 4,438,144

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Claims for Patent: 4,438,144

Title: Amino acid preparation and therapy for treatment of stress and injury
Abstract:Disclosed is a novel nutritional branched chain amino acid composition and its use for treatment of a patients suffering stress or injury, especially useful for parenteral or enteral alimentation of a patient suffering total or partial dysfunction or disuse of the gastrointestinal tract. The novel composition promotes and even optimizes patient wound healing, immune competence, host defense, and/or survival. The amino acids comprise from about 70 to 100% valine, isoleucine, and leucine, collectively, in a ratio of A:B:C, respectively, where A, B and C each independently has value from about 1 to 2. The novel composition is preferably used in the form of a parenteral infusion solution of from about 2 to 6%, most preferably 4% concentration.
Inventor(s): Blackburn; George L. (Cambridge, MA)
Assignee:
Application Number:06/373,125
Patent Claims: 1. A method of nutritional therapy for a patient suffering from physical injury or metabolic stress, said patient having a normalized urinary nitrogen excretion of at least about 15 gr/dayand having at the same time at least a partial dysfunction of the gastrointestinal tract in order to at least partially sustain protein synthesis in said patient comprising parenterally administering to said patient an effective nutritional therapy amount of an amino acid parenteral composition in which 70 to 100% of the amino acid content consists of the branched chain amino acids, leucine, isoleucine and valine in relative proportions a:b:c wherein a, b and c are independent of each other and have a value from 1 to 2 to provide effective nutritional therapy for said patient.

2. The method of claim 1 in which the parenteral composition is a solution containing a concentration of 2 to 6% total amino acids.

3. The method of claim 1 in which the injury is trauma.

4. A method of nutritional therapy for a patient said patient having a normalized urinary nitrogen excretion of about 15 gr/day and having at least a partial dysfunction of the gastrointestinal tract in association with sepsis in order to at least partially sustain protein syntheses in said patient comprising parenterally administering to said patient an effective nutritional therapy amount of an amino acid parenteral composition in which 70 to 100% of the amino acid content consists of the branched chain amino acids consisting of leucine, isoleucine and valine in relative proportions a:b:c: wherein a, b, c are independent of each other and have a value from 1 to 2 to provide effective nutritional therapy for said patient.

5. The method of claim 4 in which the enteral composition is a solution containing a concentration of 2 to 6% total amino acids.
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