|Title:||Radiographic scanning agent|
|Abstract:||A composition and method for the preparation of a technetium-99m-based scanning agent are disclosed. The scanning agent is prepared from .sup.99m Tc, in a +3, +4 and/or +5 oxidation state, and a methanehydroxydiphosphonate bone-seeking agent which carries the radionuclide to bone mineral. The methanehydroxydiphosphonate agent provides scan sharpness equivalent or superior to commercial scanning agents, and is superior for detecting myocardial infarcts, as compared with commercial scanning agents such as ethane-1-hydroxy-1,1-diphosphonate and methanediphosphonate.|
|Inventor(s):||Bevan; John A. (Cincinnati, OH)|
|Assignee:||Mallinckrodt, Inc. (St. Louis, MO)|
1. Water-soluble stannous methanehydroxydiphosphonate.
2. Water-soluble ferrous methanehydroxydiphosphonate.
3. Water-soluble chromous methanehydroxydiphosphonate.
4. Water-soluble titanous methanehydroxydiphosphonate.
5. The water-soluble composition of matter .sup.99m Tc-methanehydroxydiphosphonate.
6. The water-soluble composition of matter .sup.99m Tc-methanehydroxydiphosphonate-tin.
7. The water-soluble composition of matter .sup.99m Tc-methanehydroxydiphosphonate-iron.
8. The water-soluble composition of matter .sup.99m Tc-methanehydroxydiphosphonate-chromium.
9. The water-soluble composition of matter .sup.99m Tc-methanehydroxydiphosphonate-titanium.