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Claims for Patent: 4,425,363

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Claims for Patent: 4,425,363

Title: Treatment of tardive dyskinesia in mammals
Abstract:A method of Treatment of Tardive Dyskinesia (TD) in humans by the administration of the compound of the formula ##STR1## or a pharmaceutically acceptable acid addition salt thereof in a non-toxic, effective therapeutic amount (calculated as base) to a human in need thereof.
Inventor(s): Stern; Warren C. (Raleigh, NC)
Assignee: Burroughs Wellcome Co. (Research Triangle Park, NC)
Application Number:06/395,118
Patent Claims: 1. A method of treating Tardive Dyskinesia in a human having Tardive Dyskinesia which comprises administering to said human an effective non-toxic Tardive Dyskinesia amount of a compound of the formula (I) ##STR3## or a pharmaceutically acceptable and acid addition salt thereof.

2. The method of claim 1 in which a pharmaceutically acceptable salt thereof is administered.

3. The method of claim 2 in which the salt is the hydrochloride salt.

4. The method of claim 1, 2, or 3 in which the compound or salt is administered in a pharmaceutically acceptable carrier therefore.

5. The method of claim 4 in which the compound or salt is administered orally.

6. The method of claim 4 in which the compound or salt is administered parenterally.

7. A method of treating Tardive Dyskinesia in a human having Tardive Dyskinesia which comprises orally administering to said human an effective acid addition Tardive Dyskinesia treatment amount of a pharmaceutically acceptable acid addition salt of the compound of the formula (I) ##STR4##

8. The method of claim 7 in which the salt is the hydrochloric salt.

9. The method of claim 7 or 8 in which the salt is administered in a pharmaceutically acceptable carrier therefor in the form of a tablet or capsule.

10. A method of treating Tardive Dyskinesia in a human having Tardive Dyskinesia which comprises parenterally administering to said human an effective non-toxic Tardive Dyskinesia treatment amount of a parenteral composition containing a pharmaceutically acceptable acid addition salt of the compound of the formula (I) ##STR5##
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