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Serving hundreds of leading biopharmaceutical companies globally:

Teva
Express Scripts
Harvard Business School
McKesson
Chubb
Covington
Colorcon
Moodys
McKinsey

Generated: April 26, 2018

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Claims for Patent: 4,418,208

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Summary for Patent: 4,418,208
Title: N-Substituted iminodiacetic acids
Abstract:Complexes of technetium-99m and a compound selected from the group having the formula ##STR1## or a pharmaceutically acceptable, water soluble salt thereof wherein R.sub.1 and R.sub.4 are each independently hydrogen, methyl or ethyl; one of R.sub.2 and R.sub.3 is alkyl of 1 to 4 carbons and the other is bromine or iodine; and n is 0, 1 or 2, are useful for the external imaging of the hepatobiliary system.
Inventor(s): Nunn; Adrian (Hopewell, NJ), Loberg; Michael (Princeton, NJ)
Assignee: E. R. Squibb & Sons, Inc. (Princeton, NJ)
Application Number:06/388,795
Patent Claims: 1. A compound having the formula ##STR6## or a pharmaceutically acceptable, water soluble salt thereof, wherein one of R.sub.2 and R.sub.3 is methyl and the other is bromine and n is 0, 1 or 2.

2. A compound in accordance with claim 1 wherein n is 0.

3. A compound having the formula ##STR7## or a pharmaceutically acceptable, water soluble salt thereof, wherein n is 0, 1 or 2.

4. A composition comprising a stannous reducing agent and a compound having the formula ##STR8## or a pharmaceutically acceptable, water soluble salt thereof, wherein one of R.sub.2 and R.sub.3 is methyl and the other is bromine and n is 0, 1 or 2.

5. A composition in accordance with claim 4 wherein n is 0.

6. A composition comprising a stannous reducing agent and a compound having the formula ##STR9## or a pharmaceutically acceptable, water soluble salt thereof, wherein n is 0, 1 or 2.

7. A composition in accordance with claim 6 wherein n is 0.

8. The compound in accordance with claim 2, 2,2'-[[2-[(3-bromo-2,4,6-trimethylphenyl)amino]-2-oxoethyl]imino]bisacetic acid.

9. The compound in accordance with claim 3, 2,2'-[[2-[(4-bromo-3-methylphenyl)amino]-2-oxoethyl]imino]bisacetic acid.

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Serving hundreds of leading biopharmaceutical companies globally:

US Army
Medtronic
Dow
Daiichi Sankyo
QuintilesIMS
Fuji
Baxter
Federal Trade Commission
Teva

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