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Claims for Patent: 4,409,212

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Claims for Patent: 4,409,212

Title: Method of preventing and treating cerebral insufficiency
Abstract:The invention relates to a method of preventing or treating cerebral insufficiency, which method comprises administering to a human being in need of such treatment, orally or rectally, a prophylactic or a therapeutically effective amount of a compound of the general formula I ##STR1## wherein X.sub.1 is hydrogen, halogen having an atomic number up to 35, or is cyano, and X.sub.2 and Y together are an additional bond, or X.sub.1 and X.sub.2 together are the oxo radical and Y is hydrogen, or X.sub.1 is hydroxy and X.sub.2 and Y are hydrogen. Examples of suitable compounds are 10,11-dihyro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide, 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide and, in particular, carbamazepine (5H-dibenz[b,f]azepine-5-carboxamide).
Inventor(s): Mondadori; Cesare (Don Mills, CA)
Assignee: Ciba-Geigy Corporation (Ardsley, NY)
Application Number:06/366,792
Patent Claims: 1. A method of preventing or treating imparied memory conditions comprising administering to a human being in need of such treatment, orally or rectally, a prophylactic or a therapeutically effective amount of a compound of the general formula ##STR3## wherein X.sub.1 is hydrogen, halogen having an atomic number up to 35, or is cyano, and X.sub.2 and Y together are an additional bond, or X.sub.1 and X.sub.2 together are the oxo radical and Y is hydrogen, or X.sub.1 is hydroxy and X.sub.2 and Y are hydrogen.

2. The method according to claim 1 wherein the impaired memory conditions comprise senile dementia, multi-infarction dementia, or Alzheimer's dementia.

3. A method according to claim 1, which comprises administration of a compound of the general formula I, wherein X.sub.1 is hydrogen, chlorine or cyano, and X.sub.2 and Y together are an additional bond, or X.sub.1 and X.sub.2 together are the oxo radical and Y is hydrogen, or X.sub.1 is hydroxy and X.sub.2 and Y are hydrogen.

4. A method according to claim 1, which comprises administration of 5H-dibenz[b,f]azepine-5-carboxamide.

5. A method according to claim 1, which comprises administration of 10,11-dihydro-10-oxo-5H-dibenz[b,f]-azepine-5-carboxamide.

6. A method according to claim 1, which comprises administration of 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]-azepine-5-carboxamide.

7. A method according to claim 1, which comprises administration of a compound of the general formula I in an amount from 2 to 17 mg/kg per day.

8. A method according to claim 18, which comprises administration of a compound of the general formula I to an adult person of normal weight in an amount from about 150 to 1200 mg per day.
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