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|Abstract:||An aqueous suspension containing methyldopa and sucrose is disclosed. This composition is an oral dosage form for treating hypertension that is bioavailable.|
|Inventor(s):||Dempski; Robert E. (Dresher, PA), O'Neill; Joseph L. (Lansdale, PA)|
|Assignee:||Merck & Co., Inc. (Rahway, NJ)|
1. A pharmaceutical composition for the oral treatment of hypertension comprising an aqueous suspension containing about 50 mg of methyldopa per ml of said suspension, about
500 mg of sucrose per ml of said suspension such that the weight ratio of methyldopa:sucrose is about 1:10.
2. The composition of claim 1 which is characterized by having bioequivalence equal or superior to a tablet containing an equivalent amount of methyldopa.
3. The composition of claim 1 wherein said aqueous suspension consists essentially of the following formulation:
4. The composition of claim 3 having bioequivalence superior to a tablet containing an equivalent amount of methyldopa.
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