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Serving leading biopharmaceutical companies globally:

Fish and Richardson
McKesson
Boehringer Ingelheim
Express Scripts
Argus Health
Medtronic
Colorcon
Dow
QuintilesIMS
Moodys

Generated: February 22, 2018

DrugPatentWatch Database Preview

Claims for Patent: 4,404,193

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Summary for Patent: 4,404,193
Title: Methyldopa composition
Abstract:An aqueous suspension containing methyldopa and sucrose is disclosed. This composition is an oral dosage form for treating hypertension that is bioavailable.
Inventor(s): Dempski; Robert E. (Dresher, PA), O'Neill; Joseph L. (Lansdale, PA)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Application Number:06/309,956
Patent Claims: 1. A pharmaceutical composition for the oral treatment of hypertension comprising an aqueous suspension containing about 50 mg of methyldopa per ml of said suspension, about 500 mg of sucrose per ml of said suspension such that the weight ratio of methyldopa:sucrose is about 1:10.

2. The composition of claim 1 which is characterized by having bioequivalence equal or superior to a tablet containing an equivalent amount of methyldopa.

3. The composition of claim 1 wherein said aqueous suspension consists essentially of the following formulation:

4. The composition of claim 3 having bioequivalence superior to a tablet containing an equivalent amount of methyldopa.

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Fish and Richardson
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Daiichi Sankyo
US Department of Justice
Harvard Business School
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Covington
Cantor Fitzgerald

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