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Claims for Patent: 4,400,358

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Claims for Patent: 4,400,358

Title: Method and adsorbant composition for .sup.82 Rb generation
Abstract:A composition comprising .sup.82 Sr and an adsorbant selected from the group consisting of tin oxide, hydrated tin oxide, polyantimonic acid, titanium oxide, and ferric oxide. A low .sup.82 Sr breakthrough method of generating .sup.82 Rb from a .sup.82 Sr charged adsorbant comprising eluting wherein said adsorbant is selected from the group consisting of tin oxide, polyantimonic acid, titanium oxide, ferric oxide, and hydrated tin oxide.
Inventor(s): Neirinckx; Rudi D. (East Windsor, NJ)
Assignee: E. R. Squibb & Sons, Inc. (Princeton, NJ)
Application Number:06/208,918
Patent Claims: 1. A composition comprising .sup.82 Sr and an adsorbant selected from the group consisting of tin oxide, hydrated tin oxide, polyantimonic acid, titanium oxide, ferric oxide, hydrated ferric oxide and hydrated titanium oxide.

2. The composition of claim 1 wherein said adsorbant is selected from the group consisting of hydrated tin oxide and polyantimonic acid.

3. The composition of claim 1 wherein said adsorbant comprises chromatotographic particles, said particles comprising hydrated tin oxide.

4. The composition of claim 3 wherein said .sup.82 Sr is adsorbed on said adsorbant chromatographic particles, said particles having an average diameter of 0.01 to 0.9 mm.

5. Apparatus for generating .sup.82 Rb comprising container means and the composition of claim 4 contained within said container means, said particles having an average diameter of 0.05 to 0.1 mm.

6. A low .sup.82 Sr breakthrough method of generating .sup.82 Rb from a .sup.82 Sr charged adsorbant comprising eluting the .sup.82 Rb from said adsorbant with an eluant solution wherein said adsorbant is selected from the group consisting of tin oxide, hydrated tin oxide, polyantimonic acid, hydrated titanium oxide, and hydrated ferric oxide.

7. The method of claim 6 wherein said adsorbant is selected from the group consisting of tin oxide, hydrated tin oxide, and polyantimonic acid.

8. The method of claim 7 further comprising providing container means and containing said .sup.82 Sr charged adsorbant in said container means, said adsorbant comprising chromatographic particles having an average diameter of 0.01 to 0.9 mm.

9. The method of claim 8 wherein said eluant solution comprises isotonic saline.

10. The method of claim 9 wherein said eluant solution further comprises a pharmaceutically acceptable buffer.

11. The method of claim 10 wherein said buffer comprises a phosphate salt or a carbonate salt.

12. The composition of claim 3 wherein said hydrated tin oxide is a substantial amount of hydrated stannic oxide.

13. The composition of claim 12 further comprising tin oxide, said composition being amorphous.
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