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Claims for Patent: 4,399,151

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Claims for Patent: 4,399,151

Title: Method of inhibiting the growth of protozoa
Abstract:.alpha.-Substituted amines and .alpha.-substituted-.alpha.-amino acids are described which are useful in inhibiting the growth of protozoa in animals.
Inventor(s): Sjoerdsma; Albert (Cincinnati, OH), McCann; Peter P. (Cincinnati, OH)
Assignee: Merrell Dow Pharmaceuticals Inc. (Cincinnati, OH)
Application Number:06/262,275
Patent Claims: 1. A method of inhibiting the growth of protozoa in animals which comprises administering a protozoal inhibiting amount of an .alpha.-substituted amino acid or an .alpha.-substituted amine having the formula ##STR35## wherein R.sub.1 is hydrogen or carboxy;

Y is selected from the group consisting of CH.sub.2 F, CHF.sub.2, CF.sub.3 and C.tbd.CH;

Z is selected from the group consisting of H.sub.2 N--(CH.sub.2).sub.3, ##STR36## and H.sub.2 N-CH.sub.2 CH.dbd.CH; with the proviso that when R.sub.1 is hydrogen, Y cannot be CF.sub.3 and Z must be ##STR37## and the salts and individual optical isomers thereof.

2. A method according to claim 1 wherein R.sub.1 is hydrogen.

3. A method according to claim 1 wherein R.sub.1 is carboxy.

4. A method according to claim 1 wherein Z is ##STR38## or H.sub.2 N--(CH.sub.2).sub.3.

5. A method according to claim 1 wherein Y is CHF.sub.2.

6. A method according to claim 1 wherein the animals are fowl and the .alpha.-substituted amino acid or .alpha.-substituted amine is administered to their drinking water at a concentration of from 0.01% to 2.0%.

7. The method according to claim 6 wherein the .alpha.-substituted amino acid or .alpha.-substituted amine is administered at a concentration of from 0.06% to 1.0%.

8. A method of inhibiting the growth of protozoa in animals which comprises administering a protozoal inhibiting amount of an .alpha.-substituted amino acid or an .alpha.-substituted amine having the formula ##STR39## wherein R.sub.1 is hydrogen or carboxy;

Y is selected from the group consisting of CH.sub.2 F, CHF.sub.2, CF.sub.3 and C.tbd.CH;

is selected from the group consisting of H.sub.2 N--(CH.sub.2).sub.3, ##STR40## and H.sub.2 N-CH.sub.2 CH.dbd.CH; with the proviso that when R.sub.1 is hydrogen, Y cannot be CF.sub.3 and Z must be ##STR41## and the salts and individual optical isomers thereof in combination with an antiprotozoal agent selected from the group consisting of Antrycide, Pentamidine, Amicarbalide and Bleomycin.

9. A method according to claim 8 wherein R.sub.1 is hydrogen.

10. A method according to claim 8 wherein R.sub.1 is carboxy.

11. A method according to claim 8 wherein Z is ##STR42## or H.sub.2 N-(CH.sub.2).sub.3.

12. A method according to claim 8 wherein Y is CHF.sub.2.

13. A method according to claim 8 wherein the animals are fowl and the .alpha.-substituted amino acid or .alpha.-substituted amine is administered to their drinking water at a concentration of from 0.01% to 2.0%.

14. A method according to claim 13 wherein the .alpha.-substituted amino acid or .alpha.-substituted amine is administered at a concentration of from 0.06% to 1.0%.

15. A method according to claim 1 wherein Y is CH.sub.2 F.

16. A method according to claim 8 wherein Y is CH.sub.2 F.
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