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Claims for Patent: 4,391,802

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Claims for Patent: 4,391,802

Title: Method of treating leukemia or leukemoid diseases
Abstract:A method of leukemia or leukemoid disease treatment by administration of a vitamin D derivative with a hydroxyl group at 1.alpha.-position is disclosed. It is believed that the vitamin D derivative with a hydroxyl group at 1.alpha.-position is capable of treating cancer through redifferentiation of cancer cells and that this capability is inherent in vitamin D derivatives with a hydroxyl group at 1.alpha.-position.
Inventor(s): Suda; Tatsuo (Tachikawa, JP), Hirasawa; Yoshihei (Niigata, JP), Takahashi; Sachio (Niigata, JP), Abe; Etsuko (Tokyo, JP), Konno; Kunio (Tokyo, JP), Aoki; Tadao (Niigata, JP)
Assignee: Chugai Seiyaku Kabushiki Kaisha (Tokyo, JP)
Application Number:06/356,385
Patent Claims: 1. A method for the treatment of leukemia or leukemoid diseases, comprising administering to a patient having such a disease an effective amount of a vitamin D derivative with a hydroxyl group at the 1.alpha.-position.

2. A method according to claim 1 wherein said derivative is administered in a soft capsule.

3. A method according to claim 1 wherein said derivative is administered in a daily dose of 0.5 to 5 .mu.g.

4. A method according to claim 1 for the treatment of leukemia, wherein the patient has leukemia.

5. A method according to claim 4 wherein the leukemia is a myelogenous leukemia.

6. A method according to claim 1 wherein said derivative is 1.alpha.-hydroxyvitamin D.sub.3.

7. A method according to claim 1 wherein said derivative is 1.alpha.,25-dihydroxyvitamin D.sub.3.

8. A method in accordance with claim 1, wherein said derivative is 1.alpha.-hydroxyvitamin D.sub.3, 1.alpha.,25-dihydroxyvitamin D.sub.3 or a mixture thereof.
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