Claims for Patent: 4,384,123

Summary for Patent: 4,384,123

Title:	Phosphinylalkanoyl substituted prolines
Abstract:	Esters of phosphinylalkanoyl prolines and phosphinylalkanoyl substituted prolines are inhibitors of angiotensin converting enzyme and are useful in the treatment of hypertension.
Inventor(s):	Edward W. Petrillo, Jr.
Assignee:	ER Squibb and Sons LLC
Application Number:	US06/326,082
Patent Claims:	1. A compound having the formula ##STR27## or a non-toxic, physiologically acceptable salt thereof, wherein R1 is alkyl, aryl, arylalkyl, cycloalkyl, or cylcoalkylalkyl;R2 and R4 each is independently hydrogen, alkyl or arylalkyl; R3 is hydrogen or alkyl; --R5 --COOR4 is ##STR28## R6 is cycloalkyl or aryl; R7 and R'7 together are --S--(CH2)2 --S--; and n is 0 or 1;and wherein the term "aryl" refers to phenyl or phenyl substituted with halogen, alkyl, alkoxy, alkylthio, hydroxy, alkanoyl, nitro, amino, dialkylamino, or trifluoromethyl groups; the term "alkyl" refers to groups having 1 to 10 carbon atoms; the term "alkoxy" refers to groups having 1 to 8 carbon atoms; the term "cycloalkyl" refers to groups having 3 to 7 carbon atoms; and the term "alkanoyl" refers to groups having 2 to 9 carbon atoms. 2. A compound in accordance with claim 1 wherein n is 0. 3. A compound in accordance with claim 1 wherein each of R2 and R4 is hydrogen. 4. A compound in accordance with claim 1 wherein --R5 --COOR4 is ##STR29## 5. A compound in accordance with claim 1 wherein --R5 --COOR4 is ##STR30## 6. The compound in accordance with claim 1, (S)-7-[[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid, or a physiologically acceptable salt thereof. 7. The compound in accordance with claim 1, (cis)-4-cyclohexyl-1-[[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-L-proline, or a physiologically acceptable salt thereof. 8. The compound in accordance with claim 1, (cis)-1-[[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-4-phenyl-L-proline, or a physiologically acceptable salt thereof.