Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving hundreds of leading biopharmaceutical companies globally:

Chubb
Federal Trade Commission
Johnson and Johnson
Farmers Insurance
Deloitte
Mallinckrodt
Daiichi Sankyo
Fuji
Teva

Generated: May 23, 2018

DrugPatentWatch Database Preview

Claims for Patent: 4,382,892

« Back to Dashboard

Summary for Patent: 4,382,892
Title: Benzoxazine derivatives
Abstract:Pyrido[1,2,3-de][1,4]benzoxazine derivatives are described having the formula (I) ##STR1## wherein X is a halogen atom, R is a hydrogen atom or an alkyl group of 1 to 6 carbon atoms and Z represents mono-substituted, di-substituted or cyclic-substituted amino group which may contain a hetero atom and may have a substituent such as hydroxyl, alkyl having 1 to 6 carbon atoms, amino, hydroxyalkyl having 1 to 6 carbon atoms or mono- or di-alkylamino having 1 to 6 carbon atoms in each alkyl moiety and the pharmaceutically acceptable salt thereof, having antibacterial activity.
Inventor(s): Hayakawa; Isao (Tokyo, JP), Hiramitsu; Tokiyuki (Tokyo, JP), Tanaka; Yoshiaki (Tokyo, JP)
Assignee: Daiichi Seiyaku Co., Ltd. (Tokyo, JP)
Application Number:06/298,816
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 4,382,892
Patent Claims: 1. A compound having the formula (I) ##STR7## wherein X is a halogen atom, R is a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms and Z represents (1) a mono-alkylamino or di-alkylamino group or (2) a cyclicamino group selected from the group consisting of azetidinyl, pyrrolidinyl, piperdinyl, morpholinyl, piperidinyl, homopiperazinyl, thiamorpholinyl and pyrazolidinyl, each of which amino groups may be substituted with a hydroxyl group, an alkyl group having 1 to 6 carbon atoms, an amino group, a hydroxyalkyl group having 1 to 6 carbon atoms or a mono- or di-alkylamino group having 1 to 6 carbon atoms in each alkyl group.

2. A compound having the formula (I) ##STR8## wherein X is a halogen atom, R is a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms and Z represents (1) a mono-alkylamino or di-alkylamino group having 1 to 6 carbon atoms in each alkyl group which may be substituted with a hydroxyl group or an amino (-NH.sub.2) group, or (2) a cyclicamino group selected from the group consisting of azetidinyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, homopiperazinyl, thiamorpholinyl and pyrazolidinyl, each of which cyclic-amino group may be substituted with a hydroxyl group, an alkyl group having 1 to 6 carbon atoms, an amino group, a hydroxyalkyl group having 1 to 6 carbon atoms or a di-alkylamino group having 1 to 6 carbon atoms in each alkyl group.

3. A compound as in claim 1, wherein Z represents a mono-substituted amino group selected from monoethylamino and monomethylamino, a di-substituted amino group selected from diethylamino and dimethylamino, and a cyclic-substituted amino group comprising a 4- to 7-membered ring selected from azetidinyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl and homopiperazinyl.

4. A compound as in claim 1, wherein R is methyl and Z is 4-methyl-1-piperazinyl.

5. A compound as in claim 1, wherein R is methyl and Z is 4-hydroxy-1-piperazinyl.

6. A compound as in claim 1, wherein R is methyl and Z is 3-hydroxy-1-pyrrolidinyl.

7. A compound as in claim 1, wherein R is methyl and Z is homopiperazinyl.

8. The compound 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[ 1,2,3-de][1,4]benzoxazine-6-carboxylic acid.

For more information try a trial or see the plans and pricing

Serving hundreds of leading biopharmaceutical companies globally:

Merck
McKinsey
Deloitte
Daiichi Sankyo
AstraZeneca
Citi
Federal Trade Commission
Colorcon
Boehringer Ingelheim

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.