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Claims for Patent: 4,382,090

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Claims for Patent: 4,382,090

Title: N-Thiazolylmethylthioalkyl-N'alkylamidines and related compounds
Abstract:N-alkyl-N'-(2-aminoalkyl-4-thiazolylmethylthio)alkyl guanidines, thioureas, ethenediamines and related compounds, H.sub.2 -receptor antagonists, useful in inhibiting gastric acid secretion in mammals.
Inventor(s): Pioch; Richard P. (Indianapolis, IN)
Assignee: Eli Lilly and Company (Indianapolis, IN)
Application Number:06/319,155
Patent Claims: 1. A pharmaceutical formulation in unit dosage form adapted for oral administration to achieve an antisecretory effect, comprising per dosage unit an antisecretorially-effective amount of N-methyl-N'-2-(2-dimethylaminomethyl-4-thiazolylmethylthio)ethyl 2-nitro-1,1-ethenediamine or a pharmaceutically acceptable acid addition salt thereof plus one or more pharmaceutical excipients.

2. A pharmaceutical formulation according to claim 1 containing from 50-80 mg. of active drug per dosage unit.

3. A method for inhibiting gastric acid secretion in mammals which comprises administering to a mammal, whose gastric acid secretion is excessive and who is in need of treatment, an antisecretorially-effective amount of N-methyl-N'-2-(2-dimethylaminomethyl-4-thiazolylmethylthio)ethyl 2-nitro-1,1-ethenediamine or a pharmaceutically acceptable acid addition salt thereof.

4. A method according to claim 3 in which from 140-350 mg. of drug per day are administered orally to humans.

5. A method according to claim 3 in which the oral daily dose is from 2-5 mg./kg. of mammalian body weight.

6. A method according to claim 3 in which the antisecretory drug is administered orally.

7. A method according to claim 3 in which the antisecretory drug is administered parenterally.
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