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Argus Health
US Army

Generated: November 19, 2017

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Claims for Patent: 4,379,785

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Claims for Patent: 4,379,785

Title: Heterocyclic substituted sulfonyl ureas, and their use
Abstract:What are disclosed are sulfonyl ureas of the formula ##STR1## in which R.sup.1, X and Y are as defined in the specification, and their physiologically acceptable salts, pharmaceutical formulations on the basis of these compounds, and their use in the treatment of diabetes.
Inventor(s): Weyer; Rudi (Kelkheim, DE), Hitzel; Volker (Hofheim am Taunus, DE), Geisen; Karl (Frankfurt am Main, DE), Regitz; Gunter (Bad Soden am Taunus, DE)
Assignee: Hoechst Aktiengesellschaft (Frankfurt am Main, DE)
Application Number:06/217,524
Patent Claims: 1. A sulfonyl urea of the formula ##STR12## or a physiologically acceptable salt thereof, wherein X is alkylene or alkenylene having from 3 to 6 carbon atoms, optionally substituted by up to 3 alkyl groups each having from 1 to 4 carbon atoms, or by phenyl;

or the group ##STR13## is a bicyclic system of the formula ##STR14## and Y is alkylene having 2 or 3 carbon atoms;

R.sup.1 is alkyl having from 4 to 6 carbon atoms, cycloalkyl, alkylcycloalkyl, dialkylcycloalkyl, cycloalkylalkyl, cycloalkenyl, or alkylcycloalkenyl in each case having 4 to 9 carbon atoms, or is methylcyclopentylmethyl, cyclohexenylmethyl, chlorocyclohexyl, methoxycyclohexyl, bicycloheptyl, bicycloheptenyl, bicycloheptylmethyl, bicycloheptenylmethyl, bicyclooctyl, nortricyclyl, adamantyl, or benzyl.

2. A compound as in claim 1 which is N-(4-[2-(3,4-dimethyl-2-oxo-3-pyrroline-1-carboxamido)-ethyl]-benzenesulfo nyl)-N'-4-methyl-cyclohexyl-urea.

3. A compound as in claim 1 which is N-(4-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)-ethyl]-benzenes ulfonyl)-N'-4-methyl-cyclohexyl-urea.

4. A compound as in claim 1 which is N-(4-[2-(3,4-dimethyl-2-oxo-3-pyrroline-1-carboxamido)-ethyl]-benzenesulfo nyl)-N'-4-ethyl-cyclohexyl-urea.

5. A pharmaceutical composition for lowering the blood sugar level, which comprises a hypoglycemically effective amount of a sulfonyl urea or salt thereof as in claim 1 in combination with a pharmaceutically acceptable carrier therefor.

6. A method for lowering the blood sugar level in a patient suffering from diabetes, which comprises orally administering a hypoglycemically effective amount of a sulfonyl urea or salt thereof as claimed in claim 1.
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Serving leading biopharmaceutical companies globally:

Harvard Business School
US Department of Justice
Queensland Health
Daiichi Sankyo

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