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Claims for Patent: 4,371,516

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Claims for Patent: 4,371,516

Title: Articles for carrying chemicals
Abstract:The invention relates to shaped articles carrying chemicals, particular to pharmaceutical dosage forms carrying pharmaceuticals, which disintegrate rapidly in water. The shaped articles comprise an open matrix network of carrier material carrying the chemical. The articles may be prepared by subliming solvent from a composition comprising the chemical and a solution of the carrier material in a solvent, the composition being in the solid state in a mould.
Inventor(s): Gregory; George K. E. (Marlow, GB2), Peach; James M. (High Wycombe, GB2), Du Mayne; James D. (Maidenhead, GB2)
Assignee: John Wyeth & Brother Limited (Maidenhead, GB2)
Application Number:06/284,025
Patent Claims: 1. A pharmaceutical dosage form for oral administration as a solid, which dosage form can be disintegrated by water within ten seconds and which consists essentially of an open matrix network carrying a unit dosage of a pharmaceutical substance, the open matrix network consisting essentially of a pharmacologically acceptable water-soluble or water-dispersible carrier material, selected from the group consisting of partially hydrolysed gelatin, hydrolysed dextran, alginate, and a mixture of at least one of the above carrier materials with polyvinyl alcohol, polyvinylpyrrolidine or acacia.

2. A process for preparing a pharmaceutical dosage form for oral administration as a solid which dosage form can be disintegrated by water within ten seconds, which process comprises subliming solvent from a composition consisting essentially of a pharmaceutical substance and a solution in a solvent of a pharmacologically acceptable water-soluble or water-dispersible carrier material selected from the group consisting of partially hydrolysed gelatin, hydrolysed dextran, alginate, and a mixture of at least one of the above carrier materials with polyvinyl alcohol, polyvinylpyrrolidine or acacia, the composition being in the solid state in a mold, corresponding in size and shape to that of the pharmaceutical dosage form, so as to produce an open matrix network of carrier material carrying the pharmaceutical substance, which matrix net-work is capable of being disintegrated by water within ten seconds.

3. The process of claim 2, wherein the composition contains a coloring agent, a flavoring agent or a preservative.

4. The process of claim 2, in which the solvent is water.

5. A method of orally administering a solid pharmaceutical dosage form to a mammal in need thereof, which comprises inserting into the mouth of said mammal a solid dosage form which can be disintegrated by water within ten seconds and which consists essentially of an open matrix network consisting essentially of a pharmacologically acceptable water-soluble or water-dispersible carrier material, selected from the group consisting of partially hydrolysed gelatin, hydrolysed dextran, alginate, and a mixture of at least one of the above carrier materials with polyvinyl alcohol, polyvinylpyrrolidine or acacia.
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