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Claims for Patent: 4,341,774

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Claims for Patent: 4,341,774

Title: Method for suppressing abnormal rise in immunological function and agent useful therefor
Abstract:A method for suppressing abnormal rise in immunological function which often causes various types of autoimmune diseases, and an agent useful therefor are disclosed. The method is carried out by administering cholecalciferol or its derivative to patients suffering from abnormal rise in immunological function. The agent contains the above compound as active ingredient and is useful not only to treat and/or prevent the abnormal rise in immunological function but also to suppress graft rejection.
Inventor(s): Aoki; Takao (Niigata, JP), Miyakoshi; Hideo (Niigata, JP), Hirasawa; Yoshihei (Niigata, JP), Nishii; Yasuo (Tokyo, JP)
Assignee: Chugai Seiyaku Kabushiki Kaisha (Tokyo, JP)
Application Number:06/176,642
Patent Claims: 1. A method for immunosuppression in humans which comprises administering cholecalciferol and/or its derivative to a human in need of immunosuppression, in an amount sufficient to suppress abnormal rise in immunological function.

2. A method according to claim 1 wherein said cholecalciferol and/or its derivative is administered in an amount of from 0.25 to 10 .mu.g/day per adult.

3. A method according to claim 2 wherein said amount is from 0.5 to 5 .mu.g/day per adult.

4. A method according to claim 1 wherein said cholecalciferol and/or its derivative is administered in an amount such that the concentration in blood of the active ingredient is from 0.01 .mu.g/ml to 1 .mu.g/ml.

5. A method in accordance with claim 1 wherein said cholecalciferol and/or its derivative is administered to a human having an autoimmune disease.

6. A method in accordance with claim 5 wherein said autoimmune disease is chronic thyroiditis, autoimmune hemolytic rheumatoid arthritis, or systemic lupus erythematosus.

7. A method in accordance with claim 1 wherein said cholecalciferol and/or its derivative is administered to a human in need of suppression of graft rejection.
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